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Using patient-derived iPSC models, the PhD study identified several gene and protein expressional changes associated with clinical manifestation and increased risk to develop schizophrenia.
“Coronary artery disease has, for a long time, been mainly treated with cholesterol-lowering drugs, but there is a need for other types of treatments as well. For example, new drugs could target pathogenic changes taking place in the arterial wall,” Professor Minna Kaikkonen-Määttä says.