Skip to main content

Refine your search

Potilas hammaslääkärillä.

A healthy mouth helps to maintain balanced metabolic profiles

Common oral infections, periodontal diseases and caries, are associated with inflammatory metabolic profiles related to an increased risk of cardiometabolic diseases, a new study by an international team of researchers suggests. Oral infections also predicted future adverse changes in metabolic profiles.  

The association between oral infections and adverse metabolic profiles was observed in the Finnish Health 2000/2011 and Parogene study cohorts.

“The observation is novel, since there are only few studies connecting extensive metabolic measures with oral infections, and no earlier prospective studies exist,” says Professor Pirkko Pussinen from the University of Eastern Finland.  

Published in Journal of Dental Research, the study also involved researchers from the University of Helsinki, Karolinska Institutet and Medical University of Graz. 

Progressed oral infections and inflammations – endodontic lesions and periodontitis – are known to be associated with an increased risk of cardiometabolic diseases. Although the mechanisms behind these associations are partially unclear, poor oral health is probably sustaining systemic inflammation. 

Especially periodontal parameters were associated with prevalent adverse metabolic profiles, whereas caries predicted unbeneficial metabolic signatures in the follow-up.