Neuro-Lymphatic // People

Group Leader Francesco Mattia Noé
PhD, Academy of Finland Research Fellow

Project researcher

Moataz Abdalkader (meningeal lymphatic vessels functionality in-vivo imaging)


Nikita Mikhailov, PhD student (development of in-vitro model to study the functionality of meningeal lymphatic vessels) – under the supervision of Prof. Rashid Giniatullin

Ville Airaksinen, MD student (characterization of T-lymphocytes infiltration in TBI perilesional cortex)

Former students
Arina Timonina

Francesco Mattia Noé details

PhD, Academy of Finland Research Fellow
Neuro-Lymphatic group
A.I. Virtanen Institute for Molecular Sciences

University of Eastern Finland
P.O. Box 1627 (Street address: Neulaniementie 2)
FIN-70211 Kuopio, Finland

Room 3434/ Bioteknia 2
phone: +358 46 902 2 902
e-mail: francesco.noe (at)

Academic Degrees

  • Ph.D. in Neuroscience at “Mario Negri” Institute for Pharmacological Research (The Open University), Milano, Italy (2010)
  • Master in Pharmacological Research at “Mario Negri” Institute for Pharmacological Research, Milano, Italy (2008)
  • MSc in Pharmaceutical Biotechnology  at Università degli Studi di Milano, Milano, Italy (2003)


  • Academy Research Fellow (2017-present) at Dept. of Neurobiology, A.I. Virtanen Institute for Molecular Science, University of Eastern Finland (Kuopio, Finland)
  • Postdoctoral Fellow (2015-2017) at Epilepsy Research Laboratory, A.I. Virtanen Institute for Molecular Science, University of Eastern Finland (Kuopio, Finland)
  • Postdoctoral Researcher (2012-2015) SOSD Neurophysiology and Experimental Neurology, Fondazione I.R.C.C.S. Istituto Neurologico “Carlo Besta” (Milano, Italy)
  • Postdoctoral Researcher (2010-2012) at Biology of Neurodegenerative Diseases Laboratory, “Mario Negri” Institute for Pharmacological Research (Milano, Italy)
  • PhD Student and Researcher (2004-2012) at Laboratory of Experimental Neurology, “Mario Negri” Institute for Pharmacological Research (Milano, Italy)

List of Relevant Publications

  1. Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology. FRIGERIO, F., FRASCA, A., WEISSBERG, I., PARRELLA, S., FRIEDMAN, A., VEZZANI, A. and NOE, F.M. (2012) Epilepsia, 53(11), pp. 1887-1897
  2. Kainic acid-induced albumin leak across the blood-brain barrier facilitates epileptiform hyperexcitability in limbic regions. NOE, F.M., BELLISTRI, E., COLCIAGHI, F., CIPELLETTI, B., BATTAGLIA, G., DE CURTIS, M. and LIBRIZZI, L. (2016) Epilepsia, 57(6), pp. 967-976
  3. Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage. LIBRIZZI, L., NOE, F.M., VEZZANI, A., DE CURTIS, M. and RAVIZZA, T. (2012) Annals of Neurology, 72(1), pp. 82-90
  4. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. RAVIZZA, T., GAGLIARDI, B., NOE, F.M., BOER, K., ARONICA, E. and VEZZANI, A. (2008) Neurobiology of disease, 29(1), pp. 142-160
  5. Increased pCREB expression and the spontaneous epileptiform activity in a BCNU-treated rat model of cortical dysplasia. PENNACCHIO, P.*, NOE, F.M.*, GNATKOVSKY, V., MORONI, R.F., ZUCCA, I., REGONDI, M.C., INVERARDI, F., DE CURTIS, M. and FRASSONI, C. (2015) Epilepsia, 56(9), pp. 1343-1354
  6. Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. NOE, F.M., POOL, A.H., NISSINEN, J., GOBBI, M., BLAND, R., RIZZI, M., BALDUCCI, C., FERRAGUTI, F., SPERK, G., DURING, M.J., PITKANEN, A. and VEZZANI, A. (2008) Brain, 131(Pt 6), pp. 1506-1515
  7. Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus. NOE, F.M., VAGHI, V., BALDUCCI, C., FITZSIMONS, H., BLAND, R., ZARDONI, D., SPERK, G., CARLI, M., DURING, M.J. and VEZZANI, A. (2010) Gene therapy, 17(5), pp. 643-652