Redox Signaling

The main goal of our group is to elucidate the role of Nrf2 in cardiovascular diseases and cancer, in order to find new targets for the prevention and treatment of these diseases.

Major research topics

  • The role of Nrf2 in vascular inflammation, lipoprotein metabolism and cardiovascular diseases.
  • The role of Nrf2 in non-alcoholic fatty liver disease and hepatosteatosis.
  • The mechanisms and consequences of Nrf2 dysregulation in cancer, and the use of Nrf2 as a pharmacological target for cancer therapy.
  • Identification of new Nrf2 target genes, with a special emphasis on microRNAs involved in cardiovascular diseases and cancer.