Drug utilization among persons with Alzheimer´s disease

Saarelainen L, Taipale H, Koponen M, Tanskanen A, Tolppanen AM, Tiihonen J, Hartikainen S. The incidence of benzodiazepine and related drug use in persons with and without Alzheimer's disease. J Alzheimer Dement 2015, epub ahead of print Oct 17.

Taipale H, Vuorikari H, Tanskanen A, Koponen M, Tiihonen J, Kettunen R, Hartikainen S. Prevalence of drug combinations increasing bleeding risk among warfarin users with and without Alzheimer's disease. Drugs & Aging 2015, epub ahead of print Oct 17.

Koponen M, Tolppanen AM, Taipale H, Tanskanen A, Tiihonen J, Johnell K, Fastbom J, Ahonen R, Hartikainen S. Incidence of antipsychotic use in relation to diagnosis of Alzheimer's disease among community-dwelling persons. Br J Psychiatry 2015; 207: 444-449.

Koponen M, Taipale H, Tanskanen A, Tolppanen AM, Tiihonen J, Ahonen R, Hartikainen S. Long-term use of antipsychotics among community-dwelling persons with Alzheimer's disease: a nationwide register-based study. Eur Psychopharmacol 2015, epub ahead of print Jul 21.

Taipale H, Koponen M, Tanskanen A, Tolppanen AM, Tiihonen J, Hartikainen S. Long-term use of benzodiazepines and related drugs among community-dwelling individuals with and without Alzheimer's disease. Int Clin Psychopharmacol 2015; 30: 202-208.

Taipale H, Koponen M, Tanskanen A, Tolppanen AM, Tiihonen J, Hartikainen S. High prevalence of psychotropic drug use among persons with and without Alzheimer's disease in Finnish nationwide cohort. Eur Neuropsychopharmacol, 2014;24:1729-37.

Torvinen-Kiiskinen S, Taipale H, Tanskanen A, Tiihonen J, Hartikainen S. Concomitant Use of Acetylcholine Esterase Inhibitors and Urinary Antispasmodics Among Finnish Community-Dwelling Persons With Alzheimer Disease. J Clin Psychopharmacol. 2014 Sep 9. [Epub ahead of print]

Imtiaz B, Tuppurainen M, Tiihonen M, Kivipelto M, Soininen H, Hartikainen S, Tolppanen AM. Oophorectomy, hysterectomy, and risk of Alzheimer's disease: a nationwide case-control study. J Alzheimers Dis. 2014;42:575-81.

Taipale H, Koponen M, Tanskanen A, Tolppanen AM, Tiihonen J, Hartikainen S. Antipsychotic doses among community-dwelling persons with Alzheimer disease in Finland. J Clin Psychopharmacol. 2014 Aug;34:435-40.

Taipale H, Koponen M, Tanskanen A, Tolppanen AM, Tiihonen J, Hartikainen S. Antipsychotic polypharmacy among a nationwide sample of community-dwelling persons with Alzheimer's disease. J Alzheimers Dis. 2014;41:1223-8.

Taipale H, Tanskanen A, Koponen M, Tolppanen AM, Tiihonen J, Hartikainen S. Antidementia drug use among community-dwelling individuals with Alzheimer's disease in Finland: a nationwide register-based study. Int Clin Psychopharmacol. 2014 Jul;29:216-23.

Gnjidic D, Hilmer SN, Hartikainen S, Tolppanen AM, Taipale H, Koponen M, Bell JS. Impact of High Risk Drug Use on Hospitalization and Mortality in Older People with and without Alzheimer's Disease: A National Population Cohort Study. PLoS One. 2014 Jan 13;9:e83224.

Tolppanen AM, Kettunen R, Ahonen R, Soininen H, Hartikainen S. Incident ischaemic heart disease in persons with Alzheimer's disease in a Finnish nationwide exposure-matched cohort. Int J Cardiol. 2013 Dec 10;170:195-201.

Tolppanen AM, Taipale H, Koponen M, Lavikainen P, Tanskanen A, Tiihonen J, Hartikainen S. Use of existing data sources in clinical epidemiology: Finnish health care registers in Alzheimer's disease research - the Medication use among persons with Alzheimer's disease (MEDALZ-2005) study. Clin Epidemiol. 2013 Aug 7;5:277-85

Tolppanen AM, Lavikainen P, Soininen H, Hartikainen S. Incident hip fractures among community dwelling persons with Alzheimer's disease in a Finnish nationwide register-based cohort. PLoS One. 2013;8:e59124.

Tolppanen AM, Lavikainen P, Solomon A, Kivipelto M, Uusitupa M, Soininen H, Hartikainen S. History of Medically Treated Diabetes and Risk of Alzheimer Disease in a Nationwide Case-Control Study. Diabetes Care 2013 Jan 22. [Epub ahead of print]

Tolppanen AM, Lavikainen P, Solomon A, Kivipelto M, Soininen H, Hartikainen S. Incidence of stroke in people with Alzheimer´s disease: a national register-based case-control study. J Alzheimers Dis. 2013;33:157-164.

Tolppanen AM, Taipale H, Koponen M, Lavikainen P, Tanskanen A, Tiihonen J, Hartikainen S. Use of existing data sources in clinical epidemiology: Finnish health care registers in Alzheimer´s disease research - the Medication use among persons with Alzheimer´s disease (MEDALZ-2005 study). Clinical Epidemiology;5:277-285:

Lönnroos E, Kyyrönen P, Bell JS, van der Cammen TJ, Hartikainen S. Risk of Death among Persons with Alzheimer's Disease: A National Register-Based Nested Case-Control Study. J Alzheimers Dis 2012;33:157-164.

Bell JS, Lönnroos E, Koivisto AM, Lavikainen P, Laitinen M-L, Soininen H, Hartikainen S. Use of antiepileptic drugs among community-dwelling persons with Alzheimer's disease in Finland. J  Alzheimers Dis 2011; 26:231-37

Laitinen M-L, Bell JS, Lavikainen P, Lönnroos E, Sulkava R, Hartikainen S. Nationwide study of antipsychotic use among community-dwelling persons with Alzheimer's disease in Finland.  Int Psychogeriatr 2011;23:1623-31.

Bell JS, Laitinen M-L, Lavikainen P, Lönnroos E, Uosukainen H, Hartikainen S. Use of strong opioids among community-dwelling persons with and without Alzheimer's disease in Finland. Pain 2011; 152:543-7.

 

Health status and survival of persons with Alzheimer´s disease

Heiskanen J, Hartikainen S, Roine RP, Tolppanen AM. 30-day mortality after cardiovascular events in persons with or without Alzheimer's disease. J Alzheimers Dis 2015;48:241-249.

Tolppanen AM, Kettunen R, Ahonen R, Soininen H, Hartikainen S. Incident ischaemic heart disease in persons with Alzheimer's disease in a Finnish nationwide exposure-matched cohort. Int J Cardiol. 2013;170:195-201.

Tolppanen AM, Lavikainen P, Soininen H, Hartikainen S. Incident hip fractures among community dwelling persons with Alzheimer's disease in a Finnish nationwide register-based cohort. PLoS One. 2013;8:e59124.

Tolppanen AM, Lavikainen P, Solomon A, Kivipelto M, Soininen H, Hartikainen S. Incidence of stroke in people with Alzheimer´s disease: a national register-based case-control study. J Alzheimers Dis. 2013;33:157-164.

Lönnroos E, Kyyrönen P, Bell JS, van der Cammen TJ, Hartikainen S. Risk of Death among Persons with Alzheimer's Disease: A National Register-Based Nested Case-Control Study. J Alzheimers Dis 2012;33:157-164.

Healthcare service use and costs among persons with Alzheimer´s disease

Taipale H, Purhonen M, Tolppanen AM, Tanskanen A, Tiihonen J, Hartikainen S. Hospital care and drug costs from 5 years before until 2 years after the diagnosis of Alzheimer's disease in a Finnish nationwide cohort. Scand J Public Health 2015, epub ahead of print Nov 9.

Tolppanen AM, Taipale H, Purmonen T, Koponen M, Soininen H, Hartikainen S. Hospital admissions, outpatient visits and healthcare costs of community-dwellers with Alzheimer's disease. Alzheimers Dement, 2015; 11: 955-963.


Methodological studies and register-based research

Tanskanen A, Taipale H, Koponen M, Tolppanen AM, Hartikainen S, Ahonen R, Tiihonen J. From prescription drug purchases to drug use periods – a second generation method (PRE2DUP). BMC Med Inform Decis Mak 2015; 15: 21.

Tanskanen A, Taipale H, Koponen M, Tolppanen AM, Hartikainen S, Ahonen R, Tiihonen J. From prescriptions to drug use periods – things to notice. BMC Research Notes 2014;7:796.

 

Risk factors for Alzheimer´s disease

Imtiaz B, Tuppurainen M, Tiihonen M, Kivipelto M, Soininen H, Hartikainen S, Tolppanen AM. Oophorectomy, hysterectomy, and risk of Alzheimer's disease: a nationwide case-control study. J Alzheimers Dis. 2014;42:575-81.

Tolppanen AM, Lavikainen P, Solomon A, Kivipelto M, Uusitupa M, Soininen H, Hartikainen S. History of Medically Treated Diabetes and Risk of Alzheimer Disease in a Nationwide Case-Control Study. Diabetes Care 2013; 36: 2015-2019.

 

Description of MEDALZ-2005 support

Tolppanen AM, Taipale H, Koponen M, Lavikainen P, Tanskanen A, Tiihonen J, Hartikainen S. Use of existing data sources in clinical epidemiology: Finnish health care registers in Alzheimer's disease research - the Medication use among persons with Alzheimer's disease (MEDALZ-2005) study. Clin Epidemiol. 2013 Aug 7;5:277-85