The University of Leeds (UoL) is a leading member of the UK’s prestigious research-intensive Russell Group universities, and is ranked within the top 100 universities worldwide. In 2017, it was named the UK University of the Year for its outstanding commitment to student education (Times Higher). The most recent Research Excellence Framework (REF) exercise identified that >82% of its research activity was either “world leading” or “internationally excellent”. Leeds hosts over 32,000 students from 141 countries attached to 560 different undergraduate and 300 postgraduate degree programmes. In 2015/16, it had an annual income in excess of €752m and its annual research income exceeded €150m of which 14.3% was derived from EU awards.

Within EDCMET, UoL will lead work-package 1, the in silico exploration of the effects of ED chemicals. Specifically, UoL will reconstruct a dynamic model of human liver metabolism, informed and validated by experimental data from the literature and other work-packages within EDCMET. We will use this model to explore how metabolic disruption by EDs can lead to fatty liver, a condition that is associated with long-term adverse health effects, including obesity, diabetes, and liver cancer. Through this approach, we aim to inform future risk assessments of the potential risk of ED exposure to human health.

Contact

Professor Nick Plant
Dean of Research Quality and Impact
Professor of Systems Biology

Email: N.Plant (at) Leeds.ac.uk