Clinical Alzheimer Research Program / Neuroimaging

Yawu Liu
MD, PhD, Adjunct Professor

Department of Clinical Radiology
Kuopio University Hospital
P.O. Box 1777
FI-70211 Kuopio, Finland

+358-(0)17-173324 (office)
+358- (0)40 355 2855 (mobile)
yawu.liu (at) kuh.fi

 

Major Positions and Appointments

  • Nov. 2008 - onwards: Researcher, Neurology, University of Eastern Finland, Finland.
  • Nov. 1998-Oct. 2008: Researcher in Department of Clinical Radiology, Kuopio University Hospital, Finland.
  • 2003 Doctor of Medicine.
  • 2008: Adjunct Professor (Docent) in Experimental Neuroradiology.
  • 1995-Oct. 1998: Attending doctor and teaching secretary in Department of Radiology, Tianjin First Central Hospital of Tianjin Medical University, China.     
  • Nov.-Dec., 1995: MRI Fellowship Training Program. Saint Joseph Central Hospital, Burbank, California, USA.
  • 1994-1997: Postgraduate School, Tianjin Medical University. Master of Diagnostic Radiology 1997.
  • 1990-1994: Resident in Radiology Department, Tianjin First Central Hospital of Tianjin Medical University, China.
  • 1985-1990: Department of Medical Imaging, Tianjin Medical University, China. Licentiate doctor 1990.

Doctoral Thesis

MRI Characterization of Human Acute Ischemic Stroke: Diffusion and Perfusion Weighted Imaging and Phase Contrast Angiography. Kuopio University, Kuopio Filnlad, 2003.

> All Publications (link)

Selected Publications

Disease Finger Print in frontotemporal degeneration with reference to Alzheimer's disease and mild cognitive impairment. M. Munoz, P. Hartikainen, A.Hall, J. Mattila, J. Koikkalainen, S-K Herukka, Y. Liu, J. Lötjönen, H. Soininen. J Alzheimers Dis. 2013 Mar 1. [Epub ahead of print]

Predicting AD conversion: comparison between prodromal AD guidelines and computer assisted PredictAD tool. Y. Liu, J. Mattila, M. Munoz, T. Paajanen, J. Koikkalainen, M. van Gils, S-K Herukka, G. Waldemar, J. Lötjönen, H. Soininen. PLoS One. 2013;8(2):e55246.

Structural MRI in frontotemporal dementia: comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry. MÁ. Muñoz-Ruiz, P. Hartikainen, J. Koikkalainen, R. Wolz, V. Julkunen, E. Niskanen, SK. Herukka, M. Kivipelto, R. Vanninen, D. Rueckert, Y. Liu, J. Lötjönen, H. Soininen. PLoS One. 2012;7(12):e52531.

Invited review: Hippocampal atrophy in Alzheimer´s disease. Neurodegenerative Disease Management. H. Soininen, Y. Liu, D. Rueckert, J. Lötjönen. 2012;2(2): 197-209.

Education increases reserve against Alzheimer's Disease – evidence from regional cortical thickness and volume measures in AD, MCI, and healthy controls. Y. Liu, V.Julkunen, T. Paajanen, Y. Zhang, E. Westman, L.O. Wahlund, A. Simmons, C. Tunnard, T. Sobow, P. Mecocci, M. Tsolaki, B. Vellas, S. Muehlboeck, A. Evans, C. Spenger, S. Lovestone, H. Soininen. Neuroradiology, 2012;54(9): 929-38.

Diffusion tensor imaging in Alzheimer's disease and mild cognitive impairment: Voxel-based analysis with Tract-Based Spatial Statistics. Y. Liu, G. Spulber, K. Lehtimäki, M. Könönen, I. Hallikainen, H. Gröhn, M. Kivipelto, M. Hallikainen, RL. Vanninen, H. Soininen. Neurobiol Aging, 2011;32(9):1558-71.

Combination Analysis of Neuropsychological Tests and Structural MRI Measures in Differentiating AD, MCI and Control Groups – the AddNeuroMed Study. Y.Liu, T. Paajanen, E. Westman, L.O. Wahlund, A. Simmons, C. Tunnard, T. Sobow, P. Mecocci, M. Tsolaki, B. Vellas, S. Muehlboeck, A. Evans, C. Spenger, S. Lovestone, H. Soininen.  Neurobiol Aging. 2011;32(7):1198-206.

Multivariate data analysis of the AddNeuroMed baseline MRI data for Alzheimer's disease, mild cognitive impairment and healthy controls. E. Westman, A. Simmons, Y. Zhang, S. Muehlboeck, C. Tunnard, Y. Liu, P. Mecocci, B. Vellas, M. Tsolaki, I. Kłoszewska, H. Soininen, S. Lovestone, C. Spenger and L.O. Wahlund.  Neuroimage, 2011;54(2): 1178-1187.

APOE ε2 allele Is Associated with Larger Regional Cortical Thicknesses and Volumes. Y. Liu, T. Paajanen, Y. Zhang, E. Westman, L.O. Wahlund, A. Simmons, C. Tunnard, T. Sobow, P. Mecocci, M. Tsolaki, B. Vellas, S. Muehlboeck, A. Evans, C. Spenger, S. Lovestone, H. Soininen.  Dementia and Geriatric Cognitive Disorders, 2010;30(3):229-37.

Effect of APOE ε4 allele on Cortical Thicknesses and Volumes – The AddNeuroMed Study. Y. Liu, T. Paajanen, Y. Zhang, E. Westman, L.O. Wahlund, A. Simmons, C. Tunnard, T. Sobow, P. Mecocci, M. Tsolaki, B. Vellas, S. Muehlboeck, A. Evans, C. Spenger, S. Lovestone, H. Soininen. Journal of Alzheimer´s Disease, 2010;21(3):947-66.

Preinterventional quantitative magnetic resonance imaging predicts uterus and leiomyoma size reduction after uterine artery embolization. P. Sipola, A. Ruuskanen, Y. Liu, M. Husso, R. Vanninen, M. Hippeläinen, H. Manninen.  JMRI. 2010 Mar;31(3):617-24.

Cerebellar apparent diffusion coefficient changes in patients with supratentorial ischemic stroke. Y. Liu, J. Karonen, J. Nuutinen, M. Könönen, E. Vanninen, JT. Kuikka, RL. Vanninen. Acta Neurol Scand, 2010 Nov;122(5):316-22.

Analyze regional volumes and thickness as predictor of conversion from mild cognitive impairment to Alzheimer's disease. Y. Liu, T. Paajanen, Y. Zhang, E. Westman, L.O. Wahlund, A. Simmons, C. Tunnard, T. Sobow, P. Mecocci, M. Tsolaki, B. Vellas, S. Muehlboeck, A. Evans, C. Spenger, S. Lovestone, H. Soininen.  Neurobiol Aging. 2010 Aug;31(8):1375-85.

Perfusion differences on SPECT and PWI in patients with acute ischemic stroke. J. Nuutinen, Y. Liu, M. Laakso, J. Karonen, E. Vanninen, J. Kuikka, H. Aronen,  R. Vanninen. Neuroradiology. 2009 Oct;51(10):687-695.

Diffusion- and perfusion-weighted MRI and MR angiography in ApoE polymorphism and acute ischemic stroke. Invited Review: Y. Liu and R. Vanninen. European Neurological Review 2009;4(2):48-50.