Molecular Basis of Aging and Alzheimer's Disease

Antero Salminen 
Research Director, Emeritus

University of Eastern Finland
Institute of Clinical Medicine / Neurology
P.O.Box 1627 (Yliopistonranta 1C)
FI-70211 Kuopio
Finland


+358-(0)50 574 07 40
antero.salminen (at) uef.fi

Academic Degrees

  • Ph.D. (Cell Biology), University of Jyväskylä, Finland, 1985
  • Docent in Cell Biology, University of Jyväskylä, 1987

Major Positions and Appointments

  • Research Associate, Academy of Finland, 1982-85 
  • Junior Research Fellow, Academy of Finland, 1987-1990
  • Senior Research Fellow, Academy of Finland, 1992-1993
  • Professor of Cell Biology, University of Jyväskylä, 1993-95 
  • Research Director, University of Kuopio, Finland, 1995- 
  • Visiting Scientist:
    • University of California, Berkeley, 1986-87 
    • National Cancer Institute, NIH, Bethesda, 1987-89
    • University of Hamburg, Medical School, Hamburg, 1990-92 
    • Baylor College of Medicine, Houston, 1993

Selected Review Articles

AGING PROCESS

Salminen A, Kaarniranta K, Kauppinen A. Regulation of longevity by FGF21: interaction between energy metabolism and stress responses. Ageing Res. Rev. 37, 79–93, 2017.

Salminen A., Kauppinen A., Kaarniranta K. FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process. J. Mol. Med. (Berl) 95, 123-131, 2017.

Salminen A, Kaarniranta K, Kauppinen A. Age-related changes in AMPK activation: Role for AMPK phosphatases and inhibitory phosphorylation by upstream signaling pathways. Ageing Res. Rev. 28, 15-26, 2016.

Salminen A, Kaarniranta K, Kauppinen A. Hypoxia-inducible histone lysine demethylases: Impact on the aging process and age-related diseases. Aging Dis. 7, 180-200, 2016.

Salminen A, Kauppinen A, Kaarniranta K. AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions. Cell. Signal. 28, 887-895, 2016.

Salminen A, Kaarniranta K, Kauppinen A. AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms. Biogerontology 17, 655-680, 2016.  

Salminen A, Kauppinen A, Kaarniranta K. 2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process. Cell. Mol. Life Sci. 72, 3897-3914, 2015.

Salminen A, Kaarniranta K, Hiltunen M, Kauppinen A. Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process. Cell. Signal. 26, 1598-1603, 2014.

Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process. Ageing Res. Rev. 16, 45-65, 2014.

Salminen A, Kaarniranta K, Hiltunen M, Kauppinen A. Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process. J. Mol. Med. (Berl) 92, 1035-1043, 2014.

Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function. Cell. Mol. Life Sci. 71, 1855-1864, 2014.

Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell. Signal., 25, 1939-1948, 2013.

Salminen A, Kaarniranta K, Kauppinen A.  Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process. Ageing Res. Rev. 12, 520-534, 2013.

Salminen A, Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res. Rev. 11, 230-241, 2012.

Salminen A, Kaarniranta K, Kauppinen A. Inflammaging: disturbed interplay between autophagy and inflammasomes. Aging (Albany NY) 4, 166-175, 2012.

Salminen A, Ojala J, Kaarniranta K, Kauppinen A. Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cell. Mol. Life Sci. 69, 2999-3013, 2012.

Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell. Signal. 24, 835-845, 2012.

Salminen A, Hyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-kB signaling and inflammation: impact on healthspan and lifespan. J. Mol. Med. (Berl) 89, 667-676, 2011.

Salminen A, Ojala J, Kaarniranta K. Apoptosis and aging: increased resistance to apoptosis enhances the aging process. Cell. Mol. Life Sci. 68, 1021-1031, 2011.

Salminen A, Kaarniranta K. Control of p53 and NF-kB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging. Cell. Signal. 23, 747-752, 2011.

Salminen A, Kaarniranta K. ER stress and hormetic regulation of the ageing process. Ageing Res. Rev. 9, 211-217, 2010.

Salminen A, Kaarniranta K. Genetics vs. entropy: longevity factors suppress the NF-κB-driven entropic aging process. Ageing Res. Rev. 9, 298-314, 2010.

Salminen A, Kaarniranta K. Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-κB signaling. Cell Signal. 22, 573-577, 2010.

Salminen A, Kaarniranta K. Regulation of the aging process by autophagy. Trends Mol. Med.15, 217-224, 2009.

Salminen A, Kaarniranta K. SIRT1: regulation of longevity via autophagy. Cell Signal. 21, 1356-1360, 2009.

Salminen A, Lehtonen M, Suuronen T, Kaarniranta K, Huuskonen J. Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential. Cell. Mol. Life Sci. 65, 2979-2999, 2008.

Salminen A, Kauppinen A, Suuronen T, Kaarniranta K. SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation? Bioessays 30, 939-942, 2008.

Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, Kaarniranta K. Interaction of aging-associated signaling cascades: inhibition of NF-κB signaling by longevity factors FoxOs and SIRT1. Cell. Mol. Life Sci. 65, 1049-1058, 2008.

Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Activation of innate immunity system during aging: NF-κB signaling is the molecular culprit of inflamm-aging. Ageing Res. Rev. 7, 83-105, 2008.

 

ALZHEIMER'S DISEASE

Salminen A, Kauppinen A, Kaarniranta K. Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease. J. Neurochem. 140, 536-549, 2017.

Salminen A, Jouhten P, Sarajärvi T, Haapasalo A, Hiltunen M. Hypoxia and GABA shunt activation in the pathogenesis of Alzheimer's disease. Neurochem. Int. 92, 13-24, 2016.

Salminen A, Haapasalo A, Kauppinen A, Kaarniranta K, Soininen H, Hiltunen M. Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. Prog. Neurobiol. 131, 1-20, 2015.

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. Prog. Neurobiol., 106-107, 33-54, 2013.

Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Prog. Neurobiol. 96, 87-95, 2012.

Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. AMP-activated protein kinase: a potential player in Alzheimer's disease. J. Neurochem. 118, 460-474, 2011.

Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H. Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype. Eur. J. Neurosci. 34, 3-11, 2011.

Salminen A, Ojala J, Kaarniranta K, Hiltunen M, Soininen H. Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Prog. Neurobiol. 93, 99-110, 2011.

Salminen A, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Inflammation in Alzheimer's disease: amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors. Prog. Neurobiol. 87, 181-194, 2009.

Salminen A, Kauppinen A, Suuronen T, Kaarniranta K, Ojala J. ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology. J. Neuroinflammation 6, 41, 2009.

Nuutinen T, Suuronen T, Kauppinen A, Salminen A.  Clusterin: a forgotten player in Alzheimer's disease. Brain Res Rev. 61, 89-104, 2009.

Salminen A, Kaarniranta K. Siglec receptors and hiding plaques in Alzheimer's disease. J. Mol. Med. (Berl) 87, 697-701, 2009.

Salminen A, Ojala J, Suuronen T, Kaarniranta K, Kauppinen A. Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology. J. Cell. Mol. Med. 12, 2255-2262, 2008.

 

AGE-RELATED MACULAR DEGENERATION (AMD)

Hyttinen J.M., Blasiak J., Niittykoski M., Kinnunen K., Kauppinen A., Salminen A., Kaarniranta K. DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD). Ageing Res. Rev. 36, 64-77, 2017.

Kauppinen A, Paterno JJ, Blasiak J, Salminen A, Kaarniranta K. Inflammation and its role in age-related macular degeneration. Cell. Mol. Life Sci. 73, 1765-1786, 2016.

Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Vereb Z, Salminen A, Boulton ME, Petrovski G. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy 9, 973-984, 2013.

Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. Age-related macular degeneration (AMD): Alzheimer's disease in the eye? J. Alzheimers Dis. 24, 615-631, 2011.

Salminen A, Kauppinen A, Hyttinen JM, Toropainen E, Kaarniranta K. Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization. Mol. Med. 16, 535-542, 2010.

Kaarniranta K, Salminen A. Age-related macular degeneration: activation of innate immunity system via pattern recognition receptors. J. Mol. Med. (Berl) 87, 117-23, 2009.

Arjamaa O, Nikinmaa M, Salminen A, Kaarniranta K. Regulatory role of HIF-1α in the pathogenesis of age-related macular degeneration (AMD). Ageing Res. Rev. 8, 349-58, 2009.