Molecular Neuropathology


Antero Salminen 
Research Director

University of Eastern Finland
Institute of Clinical Medicine / Neurology
P.O.Box 1627 (Yliopistonranta 1C)
FI-70211 Kuopio
Finland

+358-(0)50 574 07 40
antero.salminen( at )uef.fi

Academic degrees 

  • Ph.D. (Cell Biology), University of Jyväskylä, Finland, 1985
  • Docent in Cell Biology, University of Jyväskylä, 1987

Major Positions and Appointments

  • Research Associate, Academy of Finland, 1982-85 
  • Junior Research Fellow, Academy of Finland, 1987-1990
  • Senior Research Fellow, Academy of Finland, 1992-1993
  • Professor of Cell Biology, University of Jyväskylä, 1993-95 
  • Research Director, University of Kuopio, Finland, 1995- 
  • Visiting Scientist:
    • University of California, Berkeley, 1986-87 
    • National Cancer Institute, NIH, Bethesda, 1987-89
    • University of Hamburg, Medical School, Hamburg, 1990-92 
    • Baylor College of Medicine, Houston, 1993

Selected Publications

SELECTED PUBLICATIONS

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. Prog. Neurobiol. 96, 87-95, 2012.

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Salminen A, Kaarniranta K. Ageing Res. Rev. 11, 230-241, 2012.

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Salminen A, Kauppinen A, Kaarniranta K. Cell. Signal., 2012 (E-Pub.)

Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process. Salminen A, Kauppinen A, Kaarniranta K. Curr. Opin. Clin. Nutr. Metab. Care 15, 23-28, 2012.

5'adenosine monophosphate-activated protein kinase-Mammalian target of rapamycin axis as therapeutic target for age-related macular degeneration. Hyttinen JM, Petrovski G, Salminen A, Kaarniranta K. Rejuvenation Res. 14, 651-660, 2011.

Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2. Huhtiniemi T, Salo HS, Suuronen T, Poso A, Salminen A, Leppänen J, Jarho E, Lahtela-Kakkonen M. J. Med. Chem. 54, 6456-6468, 2011.

Celastrol regulates innate immunity response via NF-κB and Hsp70 in human retinal pigment epithelial cells. Paimela T, Hyttinen JM, Viiri J, Ryhänen T, Karjalainen RO, Salminen A, Kaarniranta K. Pharmacol. Res. 64, 501-508, 2011.

Cis-urocanic acid inhibits SAPK/JNK signaling pathway in UV-B exposed human corneal epithelial cells in vitro. Jauhonen HM, Kauppinen A, Paimela T, Laihia JK, Leino L, Salminen A, Kaarniranta K. Mol. Vis. 17, 2311-2317, 2011.

AMP-activated protein kinase: a potential player in Alzheimer’s disease. Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M. J. Neurochem. 118, 460-474, 2011.

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype. Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H. Eur. J. Neurosci. 34, 3-11, 2011.

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. Salminen A, Hyttinen JM, Kaarniranta K. J. Mol. Med. 89, 667-676, 2011.

Age-related macular degeneration (AMD): Alzheimer’s disease in the eye? Kaarniranta K, Salminen A, Haapasalo A, Soininen H, Hiltunen M. J. Alzheimers Dis. 24, 615-631, 2011.

Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer’s disease. Salminen A, Ojala J, Kaarniranta K, Hiltunen M, Soininen H. Prog. Neurobiol. 93, 99-110, 2011.

Apoptosis and aging: increased resistance to apoptosis enhances the aging process. Salminen A, Ojala J, Kaarniranta K. Cell. Mol. Life Sci. 68, 1021-1031, 2011.

Control of p53 and NF-κB signaling by WIP1 and MIF: Role in cellular senescence and organismal aging. Salminen A, Kaarniranta K. Cell. Signal. 23, 747-752, 2011.

Characterization of a novel transgenic rat carrying human tau with mutation P301L. Korhonen P, van Groen T, Thornell A, Kyrylenko S, Soininen ML, Ojala J, Peltomaa E, Tanila H, Salminen A, Mandelkow EM, Soininen H. Neurobiol. Ageing  32, 2314-2315, 2011.

Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization. Salminen A, Kauppinen A, Hyttinen JM, Toropainen E, Kaarniranta K. Mol. Med. 16, 535-542, 2010.

p62/sequestome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells. Viiri J, Hyttinen JM, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A, Kaarniranta K. Mol. Vis. 16, 1399-1414, 2010.

Endoplasmic reticulum stress in age-related macular degeneration: trigger for neovascularization. Salminen A, Kauppinen A, Hyttinen JM, Toropainen E, Kaarniranta K. Mol. Med. 16, 535-542, 2010.

p62/sequestome 1 as a regulator of proteasome inhibitor-induced autophagy in human retinal pigment epithelial cells. Viiri J, Hyttinen JM, Ryhänen T, Rilla K, Paimela T, Kuusisto E, Siitonen A, Urtti A, Salminen A, Kaarniranta K. Mol. Vis. 16, 1399-1414, 2010.

ER stress and hormetic regulation of the ageing process. Salminen A, Kaarniranta K. Ageing Res. Rev. 9, 211-217, 2010.

Valproic acid stimulates clusterin expression in human astrocytes: implications for Alzheimer’s disease. Nuutinen T, Suuronen T, Kauppinen A, Salminen A. Neurosci. Lett. 475, 64-68, 2010.

Genetics vs. entropy: longevity factors suppress the NF-κB-driven entropic aging process. Salminen A, Kaarniranta K. Ageing Res. Rev. 9, 298-314, 2010.

Mechanisms of protein aggregation in the retinal pigment epithelial cells. Kaarniranta K, Hyttinen J, Ryhänen T, Viiri J, Paimela T, Toropainen E, Sorri I, Salminen A.  Front Biosci. (Elite Ed.) 2, 1374-1384, 2010.

Glycolysis links p53 function with NF-κB signaling: impact on cancer and ageing process. Salminen A, Kaarniranta K. J. Cell. Physiol. 224, 1-6, 2010.

Celastrol: Molecular targets of Thunder God Vine. Salminen A, Lehtonen M, Paimela T, Kaarniranta K. Biochem. Biophys. Res. Commun. 394, 439-442, 2010.

Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-κB signaling. Salminen A, Kaarniranta K. Cell Signal. 22, 573-577, 2010.