Suositukset aineiden annosteluun ja verinäytteiden ottoon

Neulan koko ja injektiovolyymit           sc - nahan alle        im - lihakseen        iv - suonensisäisesti        ip - vatsaonteloon

Hiiri
   sc 25 G     0,5 ml
   im 27 G     0,05 ml
   iv 26-28 G 0,3 ml
   ip 25-27 G 2-3 ml
   po               0,5 ml

Rotta
   sc 25 G     2 ml
   im 25 G     0,1 ml
   iv 25-27 G 0,5-1 ml
   ip 23-25 G 4-10 ml
   po                2 ml

Kani
   sc 21-25 G        1-5 ml/kohta, yht. 20-30 ml
   im 25 G              0,5 ml
   iv 23-25 G          10 ml
   ip 21-23 G          50 ml

Diehl et al: A GOOD PRACTICE GUIDE TO THE ADMINISTRATION OF SUBSTANCES AND REMOVAL OF BLOOD, INCLUDING ROUTES AND VOLUMES – Journal of Applied Toxicology 21, 15 - 23, 2001. 

Table 1. Administration volumes considered good practice (and possible maximal dose volumes) ^a.)

 _{a.) For non-aqueous injectates, consideration must be given to time of absorption before redosing. No more than two intramuscular sites should be used per day. Subcutaneous sites should be limited to two or three sites per day. The subcutaneous site does not include Freund's adjuvant administration.
b.) Values in millilitres per site.
c.) Data not available.}

Table 2. Repeated intravenous infusion: dose volumes/rates (and possible maximal volumes/rates) ^a.) 

_{a.) For non-aqueous injectates, see text. In some cases two sets of values are shown. Those in parentheses are the possible maximal values.
b.) Based on teratology studies.
c.) Data not available.}

Table 3. Circulating blood volume in laboratory animals     

 _{a.) The recommended mean corresponds to the mid-point of the range of means.}

Table 4. Limit volumes and recovery periods  

    
Table 5. Total blood volumes and recommended maximum blood sample volumes for   species of given body weights  

Table 6. Summary of the advantages and disadvantages of the various methods of blood sampling  

_{a.) The potential for tissue damage is based on the likely incidence occurring and the severity of any sequelae, e.g. inflammatory reaction or histological damage.
b.) Only carried out as a terminal procedure under general anaesthesia.}

Table 7. Recommended sites for repeated blood sampling  

   2.6.2010sm