Randomized controlled trials in substance dependence

Research topics and goals

  • To find new effective pharmacological treatments for illicit drug dependence.

Latest achievements

  • The results from Tiihonen et al. 2012 (Am J Psychiatry) provided the first evidence from a randomized controlled trial of an effective pharmacological treatment for polysubstance dependence.

Research methods

  • Randomized controlled trials

Group leader

Professor Jari Tiihonen
Karolinska Institutet
Department of Clinical Neuroscience
K8, CPF, Byggnad R5:00
S-171 76 Stockholm
Sweden
Tel. +358 50 341 8363
e-mail: jari.tiihonen(at)ki.se

Present positions

  • Professor, Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
  • Professor, University of Eastern Finland, Department of Forensic Psychiatry, Kuopio, Finland

Major research interests

  • Psychiatry, psychopharmacology, functional brain imaging, autoradiography studies on dopamine and serotonin receptors and transporters in the human brain; epidemiology, genetics and neurobiology of substance dependence; violent and suicidal behavior

Previous major positions and appointments

  • Professor, University of Eastern Finland, Department of Forensic Psychiatry, Kuopio, Finland
  • Professor, University of Helsinki, Department of Psychiatry, Helsinki, Finland

Academic degrees

  • MD, PhD

Collaboration

  • Karolinska Institutet, Stockholm, Sweden
  • Kuopio University Hospital, the Finnish Medicines Agency, National Institute for Health and Welfare, the Helsinki Deaconess Institute, Finland
  • St. Petersburg Bekhterev Psychoneurological Research Institute, Valdman Institute of Pharmacology, Pavlov State Medical University, Russia
  • University of Auckland, New Zealand

Selected publications

Tiihonen J, Kuoppasalmi K, Föhr J, Tuomola P, Kuikanmäki O, Vorma H, Sokero P, Haukka J, Meririnne E: A comparison of aripiprazole, methylphenidate and placebo for amphetamine dependence. Am J Psychiatry 2007;164:160-162, 2007. 

Tiihonen J, Krupitsky E, Verbitskaya E, Blokhina E, Mamontova O, Föhr J, Tuomola P, Kuoppasalmi K, Kiviniemi V, Zwartau E: Naltrexone implant for the treatment of polydrug dependence. Am J Psychiatry 2012;169(5):531-6.

Miles SW, Sheridan J, Russell B, Kydd R, Wheeler A, Walters C, Gamble G, Hardley P, Jensen M, Kuoppasalmi K, Tuomola P, Föhr J, Kuikanmäki O, Vorma H, Salokangas R, Mikkonen A, Kallio M, Kauhanen J, Kiviniemi V, Tiihonen J: Extended release methylphenidate for treatment of amphetamine/methamphetamine dependence: a randomised, double-blind, placebo controlled trial. Addiction 2013;108(7):1279-86.