GenBreast

Research topics and goals

GenBreast is a case-control study with 520 Finnish breast cancer patients diagnosed between years 1990-1995. The aim of our research is to find genetic risk factors of breast cancer as well as discover genetic predictive tools for individually tailored treatment of breast cancer.

Latest achievements

  • We have found positive associations with survival and certain genetic polymorphisms that have an effect on the metabolism of cancer therapies and DNA repair.

Research methods

  • Survival analyses are conducted by Kaplan-Meier method and Cox regression analyses by different genotypes and other genetic data in specific treatment groups

Collaboration

  • Breast Cancer Association Consortium (BCAC)

Selected publications

Garcia-Closas M et al. Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics. PLoS Genet 2008; 4:e1000054. 

Hartikainen JM, Tengström M, Kosma VM, Kinnula VL, Mannermaa A, Soini Y. Genetic polymorphisms and protein expression of NRF2 and Sulfiredoxin predict survival outcomes in breast cancer. Cancer Res. 2012 Nov 1;72(21):5537-46.

Group leader

Pofessor Vesa Kataja
email: vesa.kataja (at) kuh.fi
address: Cancer Center, P.O. BOX 100, FI-70029 KYS FINLAND

Present position

  • Professor in Oncology

Major research interests

  • Breast Cancer, Prostate Cancer

Academic degrees

  • Docent

Group

Doctoral students

  • Dr Maria Tengström, breast cancer, email: maria.tengstrom(at)kuh.fi