RESEARCH ON XENOBIOTIC METABOLISM
Research Group | Description | Projects| Collaboration
Research Group 
Senior researchers:
Hannu Raunio (Professor of Pharmacology)
Markku Pasanen (Professor of Drug Toxicology)
Risto Juvonen (Senior Scientist)
Post doc researchers: Merja Häkkinen, Minna Rahnasto and Markus Storvik
PhD students: Pasi Huuskonen, Laura Korhonen, Jaana Laine, Kaisa Salminen and Niina Tani
Laboratory staff: Hannele Jaatinen and Pirjo Hänninen
Graduate students: Annually 2-5 students
Description
Xenobiotic metabolism plays a critical role in the elimination of foreign compounds in the body. Usually metabolism results in ending the effects of drugs or toxic compounds, but often the same system causes them to become active and toxic.
Projects
The xenobiotic metabolism research group at the School of Pharmacy has three main research projects:
1) Structure-activity relationships of cytochrome P450 (CYP) enzymes
2) Bioactivation reactions catalyzed by CYP enzymes
3) Function and regulation of selected CYP enzymes in placenta
Collaboration:
Academic:
- Faculty of Health Sciences, University of Eastern Finland (Prof. Antti Poso, Prof. Paavo Honkakoski, Prof. Seppo Auriola, Prof. Jarkko Rautio, Prof. Seppo Heinonen)
- Department of Pharmacology and Toxicology, University of Oulu (Prof. Olavi Pelkonen, Prof. Jukka Hakkola)
- Department of Pharmacology, University of Toronto, Toronto, Canada (Prof. Rachel Tyndale)
- Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, USA (Prof. Garold Yost)
- Minia University, Viral Hepatitis Research Lab, National Hepatology and Tropical Medicine Research Institute, Egypt (Prof. Mohamed Abdel-Hamid)
- School of Biological Sciences, University of Hong Kong, Hong Kong (Assoc. Prof. Hani El-Nezami)
Private companies:
- Hormos Medical Ltd, PharmaCity, Turku, Finland
- Nicogen Inc (Toronto, Canada)
- Novamass Analytical Ltd (Oulu, Finland)
- Orion Corporation, (Espoo, Finland)
- Xemet Ltd, Espoo Finland
- Updated 16.9.2010/PAH -
