Electron microscopy - Selected publications

Electron microscopy studies related to especially cell biology conducted in our laboratory as listed below:

2012, 2013, 2014, 2015, 2016, 2017:

Year 2017

  • Asikainen P, Dekker H, Sirviö E, Mikkonen J, Schulten E, Bloemena E, Koistinen A, ten Bruggenkate C, Kullaa A. Radiation-induced changes in microstructure of the epithelial cells of the oral mucosa – A comparative light and electron microscopic study.  Journal of Oral Pathology and Medicine. 2017; 1-7
  • Arasu UT, Kärnä R, Härkönen K, Koistinen A, Qu C, Lammi M, Rilla K. Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles. Matrix Biology, doi: https://doi.org/10.1016/j.matbio.2017.05.001
  • Juuti-Uusitalo K, Koskela A, Kivinen N, Viiri J, Hyttinen J, Reinisalo M, Koistinen A, Uusitalo H, Sinha D, Skottman H, Kaarniranta K. Autophagy regulates proteasome inhibitor-induced pigmentation in human embryonic stem cell-derived retinal pigment epithelial cells. International Journal of Molecular Sciences 2017: 18, 1089. doi: 10.3390/ijms18051089
  • Räsänen JV, Leskinen JTT, Holopainen T, Joutsensaari J, Pasanen P, Kivimäenpää M. Titanium dioxide (TiO2) fine particle capture and BVOC emissions of Betula pendula and Betula pubescens at different wind speeds. Atmospheric Environment 2017: 152, 345–353.

Year 2016

  • Korkalainen M, Täubel M, Naarala J, Kirjavainen P, Koistinen A, Hyvärinen A, Komulainen H, Viluksela M. Synergistic proinflammatory interactions of microbial toxins and structural components characteristic to moisture-damaged damaged buildings. Indoor Air 2016, doi: 10.1111/ina.12282
  • Mustonen AM, Nieminen P, Joukainen A, Jaroma A, Kääriäinen T, Kröger H, Lazaro-Ibanez E, Siljander P, Kärjä V, Härkönen K, Koistinen A, Rilla K. First in vivo detection and characterization of hyaluronan-coated extracellular vesicles in human synovial fluid. Journal of Orthopaedic Research doi:10.1002/jor.23212
  • Baltrėnaitė E, Baltrėnas P, Bhatnagar A, Vilppo T, Selenius M, Koistinen A, Penttinen OP, Dahl M. A systematic approach to using waste-derived biochar in biofiltration: a case study based on dissimilar types of waste. International Biodeterioration & Biodegradation (Accepted)
  • Laitinen K, Korhonen H, Koistinen A, Lappalainen R. Improved multilayer coatings by combined use of electrochemical and ultra-short pulsed laser deposition techniques. Surface & Coating Technology 2016, 300: 58-66

Year 2015

  • Rilla K, Koistinen AP. Correlative light and electron microscopy (CLEM) reveals the HAS3-induced dorsal plasma membrane ruffles. International Journal of Cell Biology 2015, doi:10.1155/2015/769163.
  • Koistinen V, Kärnä R, Koistinen A, Arjonen A, Tammi M, Rilla K. Cell protrusions induced by hyaluronan synthase 3 (HAS3) resemble mesothelial microvilli and share cytoskeletal features of filopodia. Experimental Cell Research 2015: 337, 179-191
  • Ukkonen H, Kumar S, Mikkonen J, Salo T, Singh SP, Koistinen A, Goormaghtigh E, Kullaa A. Changes in the microenvironment of invading melanoma and carcinoma cells identified by FTIR imaging. Vibrational Spectroscopy 2015: 79, 24-30.
  • Asikainen P, Sirviö E, Mikkonen J, Singh SP, Schulten EAJM, ten Bruggenkate CM, Koistinen AP, Kullaa AM. Microplicae – specialized cell interface between oral epithelium and saliva. Ultrastructural pathology. Early Online, 1-7, 2015.
  • Björn-Hendrik Peters, Jari T.T. Leskinen, Ferdinand Molnár, Jarkko Ketolainen. Impact of Microscale and Pilot-Scale Freeze-Drying on Protein Secondary Structures: Sucrose Formulations of Lysozyme and Catalase. Journal of Pharmaceutical Sciences, Volume 104, Issue 11, November 2015, Pages 3710-3721
  • Jacob Mensah-Attipoe, Sampo Saari, Anna-Maria Veijalainen, Pertti Pasanen, Jorma Keskinen, Jari T.T. Leskinen, Tiina Reponen. Release and characteristics of fungal fragments in various conditions. Science of The Total Environment, Volume 547, 15 March 2016, Pages 234-243

Selected publications from our customers

  • Näkki S, Rytkönen J, Nissinen T, Florea C, Riikonen J, Ek P, Zhang H, Santos HA, Närvänen A, Xu W, Lehto VP. Improved stability and biocompatibility of nanostructured silicon drug carrier for intravenous administration. Acta Biomater. 2015 Feb;13:207-15
  • Kaarniranta K, Szalai E, Smedowski A, Hegyi Z, Kivinen N, Viiri J, Wowra B, Dobrowolski D, Módis L Jr, Berta A, Wylegala E, Felszeghy S. A novel proteotoxic stress associated mechanism for macular corneal dystrophy. Histol Histopathol. 2015 Aug;30(8):921-30
  • Pesonen M, Storvik M, Kokkola T, Rysä J, Vähäkangas K, Pasanen M. Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35
  • Inna Nybom, Greta Waissi-Leinonen, Kimmo Mäenpää, Matti T. Leppänen, Jussi V.K. Kukkonen, David Werner, Jarkko Akkanen. Effects of activated carbon ageing in three PCB contaminated sediments: Sorption efficiency and secondary effects on Lumbriculus variegatus. Water Research, Volume 85, 15 November 2015, Pages 413-421

  • Greta C. Waissi-Leinonen, Inna Nybom, Kukka Pakarinen, Jarkko Akkanen, Matti T. Leppänen, Jussi V.K. Kukkonen. Fullerenes(nC60) affect the growth and development of the sediment-dwelling invertebrate Chironomus riparius larvae. Environmental Pollution, Volume 206, November 2015, Pages 17-23

Year 2014

  • Kinnunen K, Kauppinen AA, Laakso N, Koistinen A, Toropainen E, Kaarniranta K. Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures. Experimental Eye Research 2014: 120C, 82-89.
  • Asikainen P, Mikkonen JJ, Ruotsalainen TJ, Koistinen AP, Kullaa AM. Microstructure of the superficial epithelial cells of oral mucosa. Ultrastructural pathology 2014: 38, 6-12.

Selected publications from our customers

  • Qu C, Rilla K, Tammi R, Tammi M, Kröger H, Lammi MJ. Extensive CD44-dependent hyaluronan coats on human bone marrow-derived mesenchymal stem cells produced by hyaluronan synthases HAS1, HAS2 and HAS3. Int J Biochem Cell Biol. 2014 Mar;48:45-54.
  • Rilla K, Siiskonen H, Tammi M, Tammi R. Hyaluronan-coated extracellular vesicles--a novel link between hyaluronan and cancer. Adv Cancer Res. 2014;123:121-48.
  • Kivimäenpää M, Riikonen J, Sutinen S, Holopainen T. Cell structural changes in the mesophyll of Norway spruce needles by elevated ozone and elevated temperature in open-field exposure during cold acclimation. Tree Physiol. 2014 Apr;34(4):389-403.

Year 2013

  • Pöllänen M, Suihkonen R, Nevalainen K, Koistinen AP, Suvanto M, Vuorinen J, Pakkanen TT. Morphological, Mechanical, Tribological, and Thermal Expansion Properties of Organoclay Reinforced Polyethylene Composites. Polymer Engineering and Science.2013: 53, 1279-1286.
  • Qu C, Myllymaa S, Prittinen J, Koistinen A, Lappalainen R, Lammi MJ. Osteoblast behavior on various ultra short pulsed laser deposited surface coatings. Journal of Materials Science and Engineering C 2013: 33, 1676-1682.

Selected publications from our customers

  • Kaivosoja E, Myllymaa S, Takakubo Y, Korhonen H, Myllymaa K, Konttinen YT, Lappalainen R, Takagi M. Osteogenesis of human mesenchymal stem cells on micro-patterned surfaces. J Biomater Appl. 2013 Mar;27(7):862-71.
  • Rilla K, Pasonen-Seppänen S, Deen AJ, Koistinen VV, Wojciechowski S, Oikari S, Kärnä R, Bart G, Törrönen K, Tammi RH, Tammi MI. Hyaluronan production enhances shedding of plasma membrane-derived microvesicles. Exp Cell Res. 2013 Aug 1;319(13):2006-18.
  • Viiri J, Amadio M, Marchesi N, Hyttinen JM, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. PLoS One. 2013 Jul 29;8(7):e69563.
  • Klettner A, Kauppinen A, Blasiak J, Roider J, Salminen A, Kaarniranta K. Cellular and molecular mechanisms of age-related macular degeneration: from impaired autophagy to neovascularization. Int J Biochem Cell Biol. 2013 Jul;45(7):1457-67.

Year 2012

  • Lammi MJ, Qu C, Prittinen J, Kröger H, Koistinen A, Myllymaa S, Lappalainen R. Adhesion and spreading of different skeletal cell types on variable surface coatings. IEEE Xplore Trans Biomed Eng Infor 2012: 582-587
  • Asikainen P, Ruotsalainen T, Mikkonen J, Koistinen A, ten Bruggenkate C, Kullaa A. The defense architecture of the superficial cells of the oral mucosa. Medical hypotheses 2012; 78:790-2.