Frontotemporal Lobar Degeneration and
Early Onset Dementia: Multiple Sclerosis

Anne Remes
Professor of Neurology
Deputy Head of the Institute of Clinical Medicine, Director of Doctoral Programme of Clinical Research

Department of Neurology
Building 4, 5th floor
Kuopio University Hospital
Kuopio, Finland

+358- (0)44-717 4655
+358-(0)17-172 305 (fax)
anne.remes (at) uef.fi

Present Position

  • Professor of Neurology

Academic Degrees

  • M.D., University of Oulu, 1991
  • Ph.D., University of Oulu, 1993
  • Specialist in Neurology, University of Oulu, 2000 
  • Docent of Neurology, University of Oulu, 2005
  • Professor, University of Eastern Finland, 2012

Major Research Interest

  • Frontotemporal lobar degeneration

  • Early onset dementia and other memory problems of working age people

  • Multiple sclerosis

PhD STUDENTS / Frontotemporal Lobar Degeneration and Early Onset Dementia Research Group

  • Eino Solje, BM
  • Ramona Haanpää, BM
  • Jaakko Huovinen, BM
  • Noora Suhonen, MA
  • Riikka Rytty, BM
  • Fanni Haapalinna, BM
  • Mikko Moisala, BM
  • Anna Junttila (nee Kämäläinen), MD

PhD STUDENTS / Multiple Sclerosis Research Group

  • Alma Mikkola, BM
  • Marja Niiranen, MD
  • Tiina Mustonen, BM

Major Positions and Appointments

  • Assistant, acting, Department of Medical Biochemistry, University of Oulu, 1987-1993
  • Resident Physician, Department of Neurology, Oulu University Hospital, 1995-1999
  • Specialist Physician, Department of Neurology, Oulu University Hospital, 2001-2002
  • Assistant Lecturer, Department of Neurology, University of Oulu, 1999-2000, 2003-2009
  • Clinical Lecturer, Department of Neurology, University of Oulu, 2010-2012
  • Professor, Department of Neurology, University of Eastern Finland, 2012-

Selected Publications

Haanpää RM, Suhonen NM, Hartikainen P, Koivisto AM, Moilanen V, Herukka SK, Hänninen T, Remes AM. The CERAD Neuropsychological Battery in Patients with Frontotemporal Lobar Degeneration. Dement Geriatr Cogn Dis Extra. 2015 Apr 14;5(1):147-54. doi:10.1159/000380815.

Solje E, Aaltokallio H, Koivumaa-Honkanen H, Suhonen NM, Moilanen V, Kiviharju A, Traynor B, Tienari PJ, Hartikainen P, Remes AM. The Phenotype of the C9ORF72 Expansion Carriers According to Revised Criteria for bvFTD. PLoS One. 2015 Jul 6;10(7):e0131817. doi: 10.1371/journal.pone.0131817.

Kämäläinen A, Herukka SK, Hartikainen P, Helisalmi S, Moilanen V, Knuuttila A, Jansson L, Tienari PJ, Remes AM. Cerebrospinal fluid biomarkers for Alzheimer's disease in patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis with the C9ORF72 repeat expansion. Dement Geriatr Cogn Disord. 2015;39(5-6):287-93. doi: 10.1159/000371704.

Solje E, Hartikainen P, Valori M, Vanninen R, Tiihonen J, Hakola P, Tienari PJ, Remes AM. The C9ORF72 expansion does not affect the phenotype in Nasu-Hakola disease with the DAP12 mutation. Neurobiology of Aging. 2014:35;1780.e13-7. doi: 10.1016/j.neurobiolaging.2014.01.149.

Krökki O, Bloigu R, Ansakorpi H, Reunanen M, Remes AM. Neurological comorbidity and survival in multiple sclerosis. Mult Scler Relat Disord. 2014 Jan;3(1):72-7. doi: 10.1016/j.msard.2013.06.006.

Genetic and molecular aspects of frontotemporal lobar degeneration. Review. Haapasalo A, Remes AM. Current Genetic Medical Reports, 2014. doi: 10.1007/s40142-014-0063

Majounie E, Renton A, Mok K, Dopper EG, Waite A, Rollinson S, Chio A, Restagno G, Nicolaou N, Simon-Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, Orrell RW, Mead S, Sidle KC, Houlden H, Rohrer JD, Morrison KE, Pall H, Talbot K, Ansorge O, The Chromosome 9-ALS/FTD Consortium, The French research network on FTD/FTLD/ALS, The ITALSGEN Consortium, Hernandez DG, Arepalli S, Sabatelli M, Mora G, Corbo M, Giannini F, Calvo A, Englund E, Bogheroni G, Luca Floris G, Remes AM, Laaksovirta H, McCluskey L, Trojanowski JQ, Van Deerlin VM, Schellenberg GD, Nalls MA, Drory VE, Lu C-S, Yeh T-H, Ishiura H, Takahashi Y, Tsuji S, Le Ber I, Brice A, Drepper C, Williams N, Kirby J, Shawn P, Hardy J, Tienari PJ, Heutink P, Morris HR, Pickering-Brown S, Traynor BJ. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyoltrophic lateral sclerosis and frontotemporal dementia: a cross-section study. Lancet Neurology 2012; March 9, 2012 DOI:10.1016/S1474-4422(12)70043-1 [Epub ahead of print].

Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 2012;482:216-20. doi: 10.1038/nature10821.

Renton AE, Majounie E, Waite A, Simon-Sanchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau H, Abramzon Y, Remes AM, Kaganovich A, Scholz SW, Duckworth J, Ding J, Harmer DW, Hernandez DG, Johnson JO, Mok K, Ryten M, Trabzuni D, Guerreiro RJ, Orrell RW, Neal J, Murray A, Pearson J, Jansen IE, Sondervan D, Seelaar H, Blake D, Young K, Halliwell N, Callister JB, Toulson G, Richardson A, Gerhard A, Snowden J, Mann D, Neary D, Nalls MA, Peuralinna T, Jansson L, Isoviita VM, Kaivorinne AL, Hölttä-Vuori M, Ikonen E, Sulkava R, Benatar M, Wuu J, Chiò A, Restagno G, Borghero G, Sabatelli M; ITALSGEN Consortium, Heckerman D, Rogaeva E, Zinman L, Rothstein JD, Sendtner M, Drepper C, Eichler EE, Alkan C, Abdullaev Z, Pack SD, Dutra A, Pak E, Hardy J, Singleton A, Williams NM, Heutink P, Pickering-Brown S, Morris HR, Tienari PJ, Traynor BJ. A hexanucleotide repeat expansion in C9ORF72 is the cause of choromosome 9p21-linked amyotrophic lateral sclerosis-frontotemporal dementia. Neuron 2011;72:257-68.

Krökki O, Bloigu R, Reunanen M, Remes AM. Increasing incidence of multiple sclerosis in women in Northern Finland. Mult Scler 2011;17:133-8.