Clinical Epileptology

Reetta Kälviäinen
Professor in Clinical Epileptology

Visiting address:
Kuopio Epilepsy Center/Neurocenter
Building 1 A, 1st floor
Kuopio University Hospital
Puijonlaaksontie 2
70210 Kuopio
Finland

+358-40-5839249
+358-17-17-3031 (fax)
reetta.kalviainen (at) uef.fi

Present Positions

  • Professor of Clinical Epileptology
  • Director of Kuopio Epilepsy Center

Major Current Positions of Trust

  • Member of Commission of European Affairs of International League Against Epilepsy (ILAE) 2009-2013
  • Chair of the Epilepsy Scientist Panel of European Federation of Neurological Societies (EFNS) 2013-
  • President of the Finnish Brain Council (National Council of the European Brain Council) 2012-

Major Reserch Interests

Kuopio Epilepsy Center at Kuopio University Hospital is a Finnish national tertiary center dedicated to the diagnostic evaluation, therapy, and surgery of difficult epilepsy. Epilepsy research functions as an umbrella of basic and applied neuroscience at UEF campus, utilizing the Unique Window to the Living Brain that modern epileptology and epilepsy surgery provide.

Selected Publications

TMS-EEG reveals impaired intracortical interactions and coherence in Unverricht-Lundborg type progressive myoclonus epilepsy (EPM1). Julkunen P, Säisänen L, Könönen M, Vanninen R, Kälviäinen R, Mervaala E. Epilepsy Res. 2013 Apr 30. doi:pii: S0920-1211(13)00103-4. 10.1016/j.eplepsyres.2013.04.001. [Epub ahead of print] PubMed PMID: 23642573.

Infertility treatment and umbilical cord length-novel markers of childhood epilepsy? Räisänen S, Sokka A, Georgiadis L, Harju M, Gissler M, Keski-Nisula L, Kälviäinen R, Heinonen S. PLoS One. 2013;8(2):e55394. doi: 10.1371/journal.pone.0055394. Epub 2013 Feb 13. PubMed PMID: 23418441; PubMed Central PMCID: PMC3572083.

Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Guerreiro C, Kälviäinen R, Mattson R, French JA, Perucca E, Tomson T; ILAE Subcommission on AED Guidelines. Epilepsia. 2013 Mar;54(3):551-63. doi: 10.1111/epi.12074. Epub 2013 Jan 25. Review. PubMed PMID: 23350722.

Thickened skull, scoliosis and other skeletal findings in Unverricht-Lundborg disease link cystatin B function to bone metabolism. Suoranta S, Manninen H, Koskenkorva P, Könönen M, Laitinen R, Lehesjoki AE, Kälviäinen R, Vanninen R. Bone.2012 Dec;51(6):1016-24. doi: 10.1016/j.bone.2012.08.123. Epub 2012 Aug 23. PubMed PMID: 23010349.

KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy. Trinka E, Marson AG, Van Paesschen W, Kälviäinen R, Marovac J, Duncan B, Buyle S, Hallström Y, Hon P, Muscas GC, Newton M, Meencke HJ, Smith PE, Pohlmann-Eden B; for the KOMET Study Group. J Neurol Neurosurg Psychiatry. 2012 Aug 29. [Epub ahead of print] PubMed PMID: 22933814.

Sensorimotor, visual, and auditory cortical atrophy in Unverricht-Lundborg disease mapped with cortical thickness analysis. Koskenkorva P, Niskanen E, Hyppönen J, Könönen M, Mervaala E, Soininen H, Kälviäinen R, Vanninen R. AJNR Am J Neuroradiol. 2012 May;33(5):878-83. doi: 10.3174/ajnr.A2882. Epub 2012 Jan 19. PubMed PMID: 22268086.

The effect of fMRI task combinations on determining the hemispheric dominance of language functions. Niskanen E, Könönen M, Villberg V, Nissi M, Ranta-Aho P, Säisänen L, Karjalainen P, Aikiä M, Kälviäinen R, Mervaala E, Vanninen R. Neuroradiology. 2012 Apr;54(4):393-405. doi: 10.1007/s00234-011-0959-7. Epub 2011 Sep 20. PubMed PMID: 21932015; PubMed Central PMCID: PMC3304062.

Efficacy and safety of pregabalin versus lamotrigine in patients with newly diagnosed partial seizures: a phase 3, double-blind, randomised, parallel-group trial. Kwan P, Brodie MJ, Kälviäinen R, Yurkewicz L, Weaver J, Knapp LE. Lancet Neurol. 2011 Oct;10(10):881-90. doi: 10.1016/S1474-4422(11)70154-5. Epub 2011 Aug 31. PubMed PMID: 21889410.

Severer phenotype in Unverricht-Lundborg disease (EPM1) patients compound heterozygous for the dodecamer repeat expansion and the c.202C>T mutation in the CSTB gene. Koskenkorva P, Hyppönen J, Aikiä M, Mervaala E, Kiviranta T, Eriksson K, Lehesjoki AE, Vanninen R, Kälviäinen R. Neurodegener Dis. 2011;8(6):515-22. doi: 10.1159/000323470. Epub 2011 Jul 15. PubMed PMID: 21757863.

Motor cortical plasticity is impaired in Unverricht-Lundborg disease. Danner N, Säisänen L, Määttä S, Julkunen P, Hukkanen T, Könönen M, Hyppönen J, Kälviäinen R, Mervaala E. Mov Disord. 2011 Sep;26(11):2095-100. doi: 10.1002/mds.23813. Epub 2011 Jun 9. PubMed PMID: 21661050.

Long-term epilepsy surgery outcomes in patients with MRI-negative temporal lobe epilepsy. Immonen A, Jutila L, Muraja-Murro A, Mervaala E, Äikiä M, Lamusuo S, Kuikka J, Vanninen E, Alafuzoff I, Ikonen A, Vanninen R, Vapalahti M, Kälviäinen R. Epilepsia. 2010 Nov;51(11):2260-9. doi: 10.1111/j.1528-1167.2010.02720.x. Epub 2010 Sep 24. PubMed PMID: 21175607.

Primary motor cortex alterations in a compound heterozygous form of Unverricht-Lundborg disease (EPM1). Danner N, Julkunen P, Könönen M, Hyppönen J, Koskenkorva P, Vanninen R, Lehesjoki AE, Kälviäinen R, Mervaala E. Seizure. 2011 Jan;20(1):65-71. doi: 10.1016/j.seizure.2010.10.010. Epub 2010 Nov 12. PubMed PMID: 21075014.

Non-invasive preoperative localization of primary motor cortex in epilepsy surgery by navigated transcranial magnetic stimulation. Säisänen L, Könönen M, Julkunen P, Määttä S, Vanninen R, Immonen A, Jutila L, Kälviäinen R, Jääskeläinen JE, Mervaala E. Epilepsy Res. 2010 Dec;92(2-3):134-44. doi: 10.1016/j.eplepsyres.2010.08.013. Epub 2010 Sep 21. PubMed PMID: 20863666.

Is reduced ornithine-δ-aminotransferase activity the cause of vigabatrin-associated visual field defects? Sorri I, Brigell MG, Mályusz M, Mahlamäki E, de Meynard C, Kälviäinen R. Epilepsy Res. 2010 Nov;92(1):48-53. doi: 10.1016/j.eplepsyres.2010.08.006. Epub 2010 Sep 17. PubMed PMID: 20850272.

Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Kasperaviciūte D, Catarino CB, Heinzen EL, Depondt C, Cavalleri GL, Caboclo LO, Tate SK, Jamnadas-Khoda J, Chinthapalli K, Clayton LM, Shianna KV, Radtke RA, Mikati MA, Gallentine WB, Husain AM, Alhusaini S, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Heuser K, Amos L, Ortega M, Zumsteg D, Wieser HG, Steinhoff BJ, Krämer G, Hansen J, Dorn T, Kantanen AM, Gjerstad L, Peuralinna T, Hernandez DG, Eriksson KJ, Kälviäinen RK, Doherty CP, Wood NW, Pandolfo M, Duncan JS, Sander JW, Delanty N, Goldstein DB, Sisodiya SM. Brain. 2010 Jul;133(Pt 7):2136-47. doi: 10.1093/brain/awq130. Epub 2010 Jun 3. PubMed PMID: 20522523; PubMed Central PMCID: PMC2892941.

Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. Heinzen EL, Radtke RA, Urban TJ, Cavalleri GL, Depondt C, Need AC, Walley NM, Nicoletti P, Ge D, Catarino CB, Duncan JS, Kasperaviciūte D, Tate SK, Caboclo LO, Sander JW, Clayton L, Linney KN, Shianna KV, Gumbs CE, Smith J, Cronin KD, Maia JM, Doherty CP, Pandolfo M, Leppert D, Middleton LT, Gibson RA, Johnson MR, Matthews PM, Hosford D, Kälviäinen R, Eriksson K, Kantanen AM, Dorn T, Hansen J, Krämer G, Steinhoff BJ, Wieser HG, Zumsteg D, Ortega M, Wood NW, Huxley-Jones J, Mikati M, Gallentine WB, Husain AM, Buckley PG, Stallings RL, Podgoreanu MV, Delanty N, Sisodiya SM, Goldstein DB. Am J Hum Genet. 2010 May 14;86(5):707-18. doi: 10.1016/j.ajhg.2010.03.018. Epub 2010 Apr 15. PubMed PMID: 20398883; PubMed Central PMCID: PMC2869004.

Can BIS monitoring be used to assess the depth of propofol anesthesia in the treatment of refractory status epilepticus? Musialowicz T, Mervaala E, Kälviäinen R, Uusaro A, Ruokonen E, Parviainen I. Epilepsia. 2010 Aug;51(8):1580-6. doi: 10.1111/j.1528-1167.2009.02514.x. Epub 2010 Feb 3. PubMed PMID: 20132290.

Pregabalin in partial seizures: a pragmatic 21-week, open-label study (PREPS). Ryvlin P, Kälviäinen R, Von Raison F, Giordano S, Emir B, Chatamra K. Eur J Neurol. 2010 May;17(5):726-32. doi: 10.1111/j.1468-1331.2009.02916.x. Epub 2010 Jan 25. PubMed PMID: 20113339.

Carisbamate as adjunctive treatment of partial onset seizures in adults in two randomized, placebo-controlled trials. Sperling MR, Greenspan A, Cramer JA, Kwan P, Kälviäinen R, Halford JJ, Schmitt J, Yuen E, Cook T, Haas M, Novak G. Epilepsia. 2010 Mar;51(3):333-43. doi: 10.1111/j.1528-1167.2009.02318.x. Epub 2009 Oct 27. PubMed PMID: 19863578.

Motor cortex and thalamic atrophy in Unverricht-Lundborg disease: voxel-based morphometric study. Koskenkorva P, Khyuppenen J, Niskanen E, Könönen M, Bendel P, Mervaala E, Lehesjoki AE, Kälviäinen R, Vanninen R. Neurology. 2009 Aug 25;73(8):606-11. doi: 10.1212/WNL.0b013e3181b3888b. PubMed PMID: 19704079.

Altered cortical inhibition in Unverricht-Lundborg type progressive myoclonus epilepsy (EPM1). Danner N, Julkunen P, Khyuppenen J, Hukkanen T, Könönen M, Säisänen L, Koskenkorva P, Vanninen R, Lehesjoki AE, Kälviäinen R, Mervaala E. Epilepsy Res. 2009 Jul;85(1):81-8. doi: 10.1016/j.eplepsyres.2009.02.015. Epub 2009 Mar 24. PubMed PMID: 19321308.

Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial. Halász P, Kälviäinen R, Mazurkiewicz-Beldzińska M, Rosenow F, Doty P, Hebert D, Sullivan T; SP755 Study Group. Epilepsia. 2009 Mar;50(3):443-53. doi: 10.1111/j.1528-1167.2008.01951.x. Epub 2009 Jan 17. PubMed PMID: 19183227.

Clinical picture of EPM1-Unverricht-Lundborg disease. Kälviäinen R, Khyuppenen J, Koskenkorva P, Eriksson K, Vanninen R, Mervaala E. Epilepsia. 2008 Apr;49(4):549-56. doi: 10.1111/j.1528-1167.2008.01546.x. Epub 2008 Mar 5. Review. PubMed PMID: 18325013.

Propofol and barbiturates for the anesthesia of refractory convulsive status epilepticus: pros and cons. Parviainen I, Kälviäinen R, Ruokonen E. Neurol Res. 2007 Oct;29(7):667-71. doi: 10.1179/016164107X240044. Review. PubMed PMID: 18173905.

Fertility in women with active epilepsy. Viinikainen K, Heinonen S, Eriksson K, Kälviäinen R. Neurology. 2007 Nov 27;69(22):2107-8. PubMed PMID: 18040017.

An assessment of the Irish population for large-scale genetic mapping studies involving epilepsy and other complex diseases. O'Dushlaine CT, Dolan C, Weale ME, Stanton A, Croke DT, Kalviainen R, Eriksson K, Kantanen AM, Gibson RA, Hosford D, Sisodiya SM, Gill M, Corvin AP, Morris DW, Delanty N, Cavalleri GL. Eur J Hum Genet. 2008 Feb;16(2):176-83. Epub 2007 Oct 31. PubMed PMID: 17971835.

Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study. Cavalleri GL, Weale ME, Shianna KV, Singh R, Lynch JM, Grinton B, Szoeke C, Murphy K, Kinirons P, O'Rourke D, Ge D, Depondt C, Claeys KG, Pandolfo M, Gumbs C, Walley N, McNamara J, Mulley JC, Linney KN, Sheffield LJ, Radtke RA, Tate SK, Chissoe SL, Gibson RA, Hosford D, Stanton A, Graves TD, Hanna MG, Eriksson K, Kantanen AM, Kalviainen R, O'Brien TJ, Sander JW, Duncan JS, Scheffer IE, Berkovic SF, Wood NW, Doherty CP, Delanty N, Sisodiya SM, Goldstein DB. Lancet Neurol. 2007 Nov;6(11):970-80. PubMed PMID: 17913586.

Increased expression of caspase 2 in experimental and human temporal lobe epilepsy. Narkilahti S, Jutila L, Alafuzoff I, Karkola K, Paljärvi L, Immonen A, Vapalahti M, Mervaala E, Kälviäinen R, Pitkänen A. Neuromolecular Med. 2007;9(2):129-44. PubMed PMID: 17627033.

ILAE treatment guidelines: evidence-based analysis of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Glauser T, Ben-Menachem E, Bourgeois B, Cnaan A, Chadwick D, Guerreiro C, Kalviainen R, Mattson R, Perucca E, Tomson T. Epilepsia. 2006 Jul;47(7):1094-120. Review. PubMed PMID: 16886973.

Community-based, prospective, controlled study of obstetric and neonatal outcome of 179 pregnancies in women with epilepsy. Viinikainen K, Heinonen S, Eriksson K, Kälviäinen R. Epilepsia. 2006 Jan;47(1):186-92. PubMed PMID: 16417548.

Cystatin C expression is associated with granule cell dispersion in epilepsy. Pirttilä TJ, Manninen A, Jutila L, Nissinen J, Kälviäinen R, Vapalahti M, Immonen A, Paljärvi L, Karkola K, Alafuzoff I, Mervaala E, Pitkänen A. Ann Neurol. 2005 Aug;58(2):211-23. PubMed PMID: 16049933.

Children exposed to valproate in utero-population based evaluation of risks and confounding factors for long-term neurocognitive development. Eriksson K, Viinikainen K, Mönkkönen A, Aikiä M, Nieminen P, Heinonen S, Kälviäinen R. Epilepsy Res. 2005 Jul;65(3):189-200. PubMed PMID: 16029946.

Hippocampal damage in newly diagnosed focal epilepsy: a prospective MRI study. Salmenperä T, Könönen M, Roberts N, Vanninen R, Pitkänen A, Kälviäinen R. Neurology. 2005 Jan 11;64(1):62-8. PubMed PMID: 15642905.

Long term outcome of temporal lobe epilepsy surgery: analyses of 140 consecutive patients. Jutila L, Immonen A, Mervaala E, Partanen J, Partanen K, Puranen M, Kälviäinen R, Alafuzoff I, Hurskainen H, Vapalahti M, Ylinen A. J Neurol Neurosurg Psychiatry. 2002 Nov;73(5):486-94. PubMed PMID: 12397139; PubMed Central PMCID: PMC1738104.

High-dose thiopental in the treatment of refractory status epilepticus in intensive care unit. Parviainen I, Uusaro A, Kälviäinen R, Kaukanen E, Mervaala E, Ruokonen E. Neurology. 2002 Oct 22;59(8):1249-51. PubMed PMID: 12391357.

Hippocampal and amygdaloid damage in partial epilepsy: a cross-sectional MRI study of 241 patients. Salmenperä T, Kälviäinen R, Partanen K, Pitkänen A. Epilepsy Res. 2001 Jul;46(1):69-82. PubMed PMID: 11395291.

Vigabatrin, a gabaergic antiepileptic drug, causes concentric visual field defects. Kälviäinen R, Nousiainen I, Mäntyjärvi M, Nikoskelainen E, Partanen J, Partanen K, Riekkinen P Sr. Neurology. 1999 Sep 22;53(5):922-6. PubMed PMID: 10496247.