Clinical Epileptology

Reetta Kälviäinen
Professor in Neurology

Visiting address:
University of Eastern Finland
Kuopio Campus
Mediteknia Building, room 3097

Yliopistonranta 1B
70210 Kuopio
Finland

+358-40-5839249
reetta.kalviainen (at) uef.fi
Twitter @rkalviainen

Present Positions

  • Professor of Neurology (person in charge of the discipline)
  • Director of tertiary Kuopio Epilepsy Center at Kuopio University Hospital, which is a member European Reference Network (ERN) for rare and complex epilepsies EpiCARE

Major Current Positions of Trust

  • Chair of the Epilepsy Scientist Panel of European Academy of Neurology (EAN)
  • Vice Chair of the Finnish Neurological Society (Chapter of EAN)
  • Delegate of Finland in EAN
  • President of the Finnish Chapter of International League Against Epilepsy (ILAE)
  • Steering Committee member of EpiCARE ERN
  • Chair of the Steering Committee of Neurocenter Finland

Major Reserch Interests

Reetta Kälväinen's special research interest is clinical epileptology including identifying biomarkers of seizure  activity, epileptogenesis, progression, and drug-resistancy in cohorts of newly diagnosed and drug-resistant chronic patients. These aspects of scientific projects are combined with therapeutic neuropharmacological and neurosurgical interventions. She is an expert of progressive myoclonus epilepsies and has collected the largest cohort of EPM1 patients in the world.

Selected Publications

Anttila, V; Bulik-Sullivan, B; Finucane, HK; Walters, RK; Bras, J; Duncan, L; Escott-Price, V; Falcone, GJ; Gormley, P; Malik, R; Patsopoulos, NA; Ripke, S; Wei, Z; Yu, D; Lee, PH; Turley, P; Grenier-Boley, B; Chouraki, V; Kamatani, Y; Berr, C; et al. [Incl Kälviäinen, Reetta 2018. Analysis of shared heritability in common disorders of the brain. SCIENCE 360 6395: eaap8757.

Baud, Maxime O; Perneger, Thomas; Racz, Attila; Pensel, Max C; Elger, Christian; Rydenhag, Bertil; Malmgren, Kristina; Cross, J Helen; McKenna, Grainne; Tisdall, Martin; Lamberink, Herm J; Rheims, Sylvain; Ryvlin, Philippe; Isnard, Jean; Mauguiere, Francois; Arzimanoglou, Alexis; Akkol, Serdar; Deniz, Kaancan; Ozkara, Cigdem; Lossius, Morten et al. [Incl Kälviäinen, Reetta]. 2018. European trends in epilepsy surgery. NEUROLOGY 91 2: E96-E106.

Ferlisi, M; Hocker, S; Trinka, E; Shorvon, S; International Steering Committee of the StEp Audit (incl. Singh, G; Kälviäinen, R; Kramer, U; Godoy, D; Newton, C; O'Brien, T; Cook, M; Rossetti, A; Groppa, S; Kumlien, E; Ercegovac, M; Yasiry, Z; Guecht, A; Wu, T; Nabbout, R; Tripathi, M; et al.). 2018. Etiologies and characteristics of refractory status epilepticus cases in different areas of the world: Results from a global audit. EPILEPSIA 59 S2: 100-107.

Hynynen, J; Pokka, T; Komulainen-Ebrahim, J; Myllynen, P; Kärppä, M; Pylvänen, L; Kälviäinen, R; Sokka, A; Jyrkilä, A; Lähdetie, J; Haataja, L; Mäkitalo, A; Ylikotila, P; Eriksson, K; Haapala, P; Ansakorpi, H; Hinttala, R; Vieira, P; Majamaa, K; Rantala, H; et al. 2018. Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma POLG1 are not associated with increased risk for valproate-induced hepatotoxicity or pancreatic toxicity: A retrospective cohort study of patients with epilepsy. EPILEPSIA (NY) [Epub ahead of print 26 Sept 2018]: 1-12.

Julkunen, Petro; Löfberg, Olli; Kallioniemi, Elisa; Hyppönen, Jelena; Kälviäinen, Reetta; Mervaala, Esa. 2018. Abnormal motor cortical adaptation to external stimulus in Unverricht-Lundborg disease (progressive myoclonus type 1, EPM1). JOURNAL OF NEUROPHYSIOLOGY 120 2: 617-623.  

Kälviäinen, Reetta; Straus, Sabine; Dogne, Jean-Michel; Bakchine, Serge; Haas, Manuel. 2018. Reducing valproate use in women with epilepsy. The Lancet Neurology 17 7: 580-581.

Shorvon, SD; Bermejo, PE; Gibbs, AA; Huberfeld, G; Kälviäinen, R. 2018. Antiepileptic drug treatment of generalized tonic-clonic seizures: An evaluation of regulatory data and five criteria for drug selection. EPILEPSY & BEHAVIOR 82: 91-103.

The International League Against Epilepsy Consortium on Complex Epilepsies; [Incl. Kälviäinen, Reetta]. 2018. Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. Nature Communications 9: 5269.

Whelan, CD; Altmann, A; Botía, JA; Jahanshad, N; Hibar, DP; Absil, J; Alhusaini, S; Alvim, MKM; Auvinen, P; Bartolini, E; Bergo, FPG; Bernardes, T; Blackmon, K; Braga, B; Caligiuri, ME; Calvo, A; Carr, SJ; Chen, J; Chen, S; Cherubini, A; et al [Incl. Kälviäinen, R]. 2018. Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study. BRAIN [ONLINE] 141 2: 391-408.

Holtkamp Martin, Beghi Ettore, Benninger Felix, Kälviäinen Reetta, Rocamora Rodrigo, Christensen Hanne. 2017. European Stroke Organisation guidelines for the management of post-stroke seizures and epilepsy. European Stroke Journal 2 2: 103-115.  

Huttunen J, Lindgren A, Kurki MI, Huttunen T, Frösen J, Koivisto T, von und zu Fraunberg M, Immonen A, Jääskeläinen JE, Kälviäinen R. 2017. Epilepsy-associated long-term mortality after aneurysmal subarachnoid hemorrhage. NEUROLOGY 89 3: 263-268.

Kantanen A-M, Kälviäinen R, Parviainen I, Ala-Peijari M, Bäcklund T, Koskenkari J, Laitio R, Reinikainen M. 2017. Predictors of hospital and one-year mortality in intensive care patients with refractory status epilepticus: a population-based study. CRITICAL CARE (ONLINE) 21 1: 1-7.

Kantanen A-M, Reinikainen M, Parviainen I, Kälviäinen R. 2017. Long-term outcome of refractory status epilepticus in adults: A retrospective population-based study. EPILEPSY RESEARCH 133: 13-21.  

Kimiskidis Vasilios K, Tsimpiris Alkiviadis, Ryvlin Philippe, Kalviainen Reetta, Koutroumanidis Michalis, Valentin Antonio, Laskaris Nikolaos, Kugiumtzis Dimitris. 2017. TMS combined with EEG in Genetic Generalized Epilepsy: A phase II diagnostic accuracy study. CLINICAL NEUROPHYSIOLOGY 128 2: 367-381.