Clinical Alzheimer Research Program

Hilkka Soininen
Dean
Professor in Neurology
MD, PhD

Faculty of Health Sciences
University of Eastern Finland
P.O. Box 1627
FI-70211 Kuopio, Finland

+358 40 573 5749
hilkka.soininen (at) uef.fi

Present Positions

  • Professor of Neurology
  • Dean of the Faculty of Health Sciences

Major Research Interests

  • Alzheimer's disease and memory disorders:
    -
    biomarkers, genetics, neuroimaging, therapy and prevention

Major Positions and Appointments

  • Lecturer, Kuopio University, 1981-1987
  • Associate Professor in Neurology, Kuopio University, 1987-1988
  • Researcher, Academy of Finland, 1988-1991, 1992-1995
  • Visiting Associate Professor, Southern Illinois University School of Medicine, Springfield, Illinois, 1988-1989
  • Professor in Neurology, 1989-1990,1995-1999, 2000-

Selected Publications

 

Pereira JB, Mijalkov M, Kakaei E, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Spenger C, Lovestone S, Simmons A, Wahlund LO, Volpe G, Westman E; AddNeuroMed consortium, for the Alzheimer's Disease Neuroimaging Initiative. Disrupted Network Topology in Patients with Stable and Progressive Mild Cognitive Impairment and Alzheimer's Disease. Cereb Cortex. 2016 May 13. pii: bhw128. [Epub ahead of print] PubMed PMID: 27178195.

Dourlen P, Fernandez-Gomez FJ, Dupont C, Grenier-Boley B, Bellenguez C, Obriot H, Caillierez R, Sottejeau Y, Chapuis J, Bretteville A, Abdelfettah F, Delay C, Malmanche N, Soininen H, Hiltunen M, Galas MC, Amouyel P, Sergeant N, Buée L, Lambert JC, Dermaut B. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Mol Psychiatry. 2016 Apr 26. doi: 10.1038/mp.2016.59. [Epub ahead of print] PubMed PMID:27113998.

Koikkalainen J, Rhodius-Meester H, Tolonen A, Barkhof F, Tijms B, Lemstra AW, Tong T, Guerrero R, Schuh A, Ledig C, Rueckert D, Soininen H, Remes AM, Waldemar G, Hasselbalch S, Mecocci P, van der Flier W, Lötjönen J. Differential diagnosis of neurodegenerative diseases using structural MRI data. Neuroimage Clin. 2016Mar 5;11:435-49. doi: 10.1016/j.nicl.2016.02.019. eCollection 2016. PubMed PMID:27104138; PubMed Central PMCID:PMC4827727.

Kurkinen KM, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, Sarajärvi T, Gabbouj S, Kurki M, Paananen J, Koivisto AM, Rauramaa T, Leinonen V, Tanila H, Soininen H, Lucas FR, Haapasalo A, Hiltunen M. SEPT8 modulates β-amyloidogenic processing of APP via affecting the sorting and accumulation of BACE1. J Cell Sci. 2016 Apr 15. pii: jcs.185215. [Epub ahead of print] PubMed PMID:27084579.

Sindi S, Hagman G, Håkansson K, Kulmala J, Nilsen C, Kåreholt I, Soininen H, Solomon A, Kivipelto M. Midlife Work-Related Stress Increases Dementia Risk in Later Life: The CAIDE 30-Year Study. J Gerontol B Psychol Sci Soc Sci. 2016 Apr 8. pii: gbw043. [Epub ahead of print] PubMed PMID:27059705.

Koivisto AM, Kurki MI, Alafuzoff I, Sutela A, Rummukainen J, Savolainen S, Vanninen R, Jääskeläinen JE, Soininen H, Leinonen V. High Risk of Dementia in Ventricular Enlargement with Normal Pressure Hydrocephalus Related Symptoms1. J Alzheimers Dis. 2016 Mar 22;52(2):497-507. doi: 10.3233/JAD-150909. PubMed PMID:27031474.

Lupton MK, Strike L, Hansell NK, Wen W, Mather KA, Armstrong NJ, Thalamuthu A, McMahon KL, de Zubicaray GI, Assareh AA, Simmons A, Proitsi P, Powell JF, Montgomery GW, Hibar DP, Westman E, Tsolaki M, Kloszewska I, Soininen H, Mecocci P, Velas B, Lovestone S; Alzheimer's Disease Neuroimaging Initiative, Brodaty H, Ames D, Trollor JN, Martin NG, Thompson PM, Sachdev PS, Wright MJ. The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume. Neurobiol Aging. 2016 Apr;40:68-77. doi:10.1016/j.neurobiolaging.2015.12.023. Epub 2016 Jan 11. PubMed PMID: 26973105.

Beishuizen CR, Stephan BC, van Gool WA, Brayne C, Peters RJ, Andrieu S, Kivipelto M, Soininen H, Busschers WB, Moll van Charante EP, Richard E. Web-Based Interventions Targeting Cardiovascular Risk Factors in Middle-Aged and Older People: A Systematic Review and Meta-Analysis. J Med Internet Res. 2016 Mar 11;18(3):e55. doi: 10.2196/jmir.5218. PubMed PMID: 26968879; PubMed Central PMCID: PMC4808240.

Franke B, Stein JL, Ripke S, Anttila V, Hibar DP, van Hulzen KJ, Arias-Vasquez A, Smoller JW, Nichols TE, Neale MC, McIntosh AM, Lee P, McMahon FJ, Meyer-Lindenberg A, Mattheisen M, Andreassen OA, Gruber O, Sachdev PS, Roiz-Santiañez R, Saykin AJ, Ehrlich S, Mather KA, Turner JA, Schwarz E, Thalamuthu A, Yao Y, Ho YY, Martin NG, Wright MJ; Schizophrenia Working Group of the Psychiatric Genomics Consortium; Psychosis Endophenotypes International Consortium; Wellcome Trust Case Control Consortium 2; Enigma Consortium, O'Donovan MC, Thompson PM, Neale BM, Medland SE, Sullivan PF. Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nat Neurosci. 2016 Mar;19(3):420-31. doi: 10.1038/nn.4228. Epub 2016 Feb 1. PubMed PMID: 26854805; PubMed Central PMCID: PMC4852730.

Orellana C, Ferreira D, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Lovestone S, Simmons A, Wahlund LO, Westman E; AddNeuronMed consortium and for the Alzheimer''s Disease Neuroimaging Initiative. Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations. Neurodegener Dis. 2016;16(1-2):77-86. doi: 10.1159/000442443. Epub 2015 Dec 19. PubMed PMID: 26726737.

Sattlecker M, Khondoker M, Proitsi P, Williams S, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Dobson RJ. Longitudinal Protein Changes in Blood Plasma Associated with the Rate of Cognitive Decline in Alzheimer's Disease. J Alzheimers Dis. 2015;49(4):1105-14. doi: 10.3233/JAD-140669. PubMed PMID: 26599049.

Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KM, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M. Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models. Neurobiol Dis. 2016 Jan;85:187-205. doi: 10.1016/j.nbd.2015.11.005. Epub 2015 Nov 10. PubMed PMID: 26563932.

Ferreira D, Cavallin L, Granberg T, Lindberg O, Aguilar C, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Soininen H, Lovestone S, Simmons A, Wahlund LO, Westman E; AddNeuroMed consortium and for the Alzheimer’s Disease Neuroimaging Initiative*. Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition. Eur Radiol. 2015 Nov 11. [Epub ahead of print] PubMed PMID: 26560730.

Håkansson K, Soininen H, Winblad B, Kivipelto M. Correction: Feelings of Hopelessness in Midlife and Cognitive Health in Later Life: A Prospective Population-Based Cohort Study. PLoS One. 2015 Nov 4;10(11):e0142465. doi:10.1371/journal.pone.0142465. eCollection 2015. PubMed PMID: 26535584; PubMed Central PMCID: PMC4633036.

Voyle N, Keohane A, Newhouse S, Lunnon K, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Hodges A, Kiddle S, Dobson RJ. A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis. J Alzheimers Dis. 2015;49(3):659-69. doi: 10.3233/JAD-150440. PubMed PMID: 26484910.

Haapasalo A, Pikkarainen M, Soininen H. Alzheimer's disease: a report from the 7th Kuopio Alzheimer symposium. Neurodegener Dis Manag. 2015 Oct;5(5):379-82. doi: 10.2217/nmt.15.31. Epub 2015 Oct 19. PubMed PMID: 26477468.

Zwan MD, Rinne JO, Hasselbalch SG, Nordberg A, Lleó A, Herukka SK, Soininen H, Law I, Bahl JM, Carter SF, Fortea J, Blesa R, Teunissen CE, Bouwman FH, van Berckel BN, Visser PJ. Use of amyloid-PET to determine cutpoints for CSF markers: A multicenter study. Neurology. 2016 Jan 5;86(1):50-8. doi: 10.1212/WNL.0000000000002081. Epub 2015 Oct 14. PubMed PMID: 26468410; PubMed Central PMCID: PMC4731290.

Laiterä T, Kurki MI, Pursiheimo JP, Zetterberg H, Helisalmi S, Rauramaa T, Alafuzoff I, Remes AM, Soininen H, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. The Expression of Transthyretin and Amyloid-β Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. J Alzheimers Dis. 2015;48(4):959-68. doi: 10.3233/JAD-150268. PubMed PMID:26444765.

Falahati F, Ferreira D, Soininen H, Mecocci P, Vellas B, Tsolaki M, Kłoszewska I, Lovestone S, Eriksdotter M, Wahlund LO, Simmons A, Westman E; AddNeuroMed consortium and the Alzheimer’s Disease Neuroimaging Initiative. The Effect of Age Correction on Multivariate Classification in Alzheimer's Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects. Brain Topogr. 2016 Mar;29(2):296-307. doi: 10.1007/s10548-015-0455-1. Epub 2015 Oct 6. PubMed PMID: 26440606; PubMed Central PMCID: PMC4754326.

Coric V, Salloway S, van Dyck CH, Dubois B, Andreasen N, Brody M, Curtis C, Soininen H, Thein S, Shiovitz T, Pilcher G, Ferris S, Colby S, Kerselaers W, Dockens R, Soares H, Kaplita S, Luo F, Pachai C, Bracoud L, Mintun M, Grill JD, Marek K, Seibyl J, Cedarbaum JM, Albright C, Feldman HH, Berman RM. Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial. JAMA Neurol. 2015 Nov;72(11):1324-33. doi: 10.1001/jamaneurol.2015.0607. PubMed PMID:26414022.

Sarajärvi T, Marttinen M, Natunen T, Kauppinen T, Mäkinen P, Helisalmi S, Laitinen M, Rauramaa T, Leinonen V, Petäjä-Repo U, Soininen H, Haapasalo A, Hiltunen M. Genetic Variation in δ-Opioid Receptor Associates with Increased β-and γ-Secretase Activity in the Late Stages of Alzheimer's Disease. J Alzheimers Dis. 2015;48(2):507-16. doi: 10.3233/JAD-150221. PubMed PMID: 26402014.

Chiam JT, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Hodges A, Lovestone S, Newhouse S, Dobson RJ, Kiddle SJ, Sattlecker M. No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease. J Alzheimers Dis. 2015;47(3):741-50. doi: 10.3233/JAD-150289. PubMed PMID: 26401708.

Miettinen PS, Jauhiainen AM, Tarkka IM, Pihlajamäki M, Gröhn H, Niskanen E, Hänninen T, Vanninen R, Soininen H. Long-Term Response to Cholinesterase Inhibitor Treatment Is Related to Functional MRI Response in Alzheimer's Disease. Dement Geriatr Cogn Disord. 2015;40(5-6):243-55. doi: 10.1159/000435948. Epub 2015 Aug 18. PubMed PMID: 26305064.

Kojoukhova M, Koivisto AM, Korhonen R, Remes AM, Vanninen R, Soininen H, Jääskeläinen JE, Sutela A, Leinonen V. Feasibility of radiological markers in idiopathic normal pressure hydrocephalus. Acta Neurochir (Wien). 2015 Oct;157(10):1709-18; discussion 1719. doi: 10.1007/s00701-015-2503-8. Epub 2015 Jul 21. PubMed PMID: 26190755.

Koivisto AM, Hallikainen I, Välimäki T, Hongisto K, Hiltunen A, Karppi P, Sivenius J, Soininen H, Martikainen J. Early psychosocial intervention does not delay institutionalization in persons with mild Alzheimer disease and has impact on neither disease progression nor caregivers' well-being: ALSOVA 3-year follow-up. Int J Geriatr Psychiatry. 2016 Mar;31(3):273-83. doi:10.1002/gps.4321. Epub 2015 Jul 14. PubMed PMID: 26177825.

Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. Health-related quality of life in patients with idiopathic normal pressure hydrocephalus. Eur J Neurol. 2015 Oct;22(10):1391-9. doi: 10.1111/ene.12755. Epub 2015 Jun 24. PubMed PMID: 26104064.

Kiddle SJ, Steves CJ, Mehta M, Simmons A, Xu X, Newhouse S, Sattlecker M, Ashton NJ, Bazenet C, Killick R, Adnan J, Westman E, Nelson S, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Curtis C, Breen G, Williams SC, Lovestone S, Spector TD, Dobson RJ. Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes. Transl Psychiatry. 2015 Jun 16;5:e584. doi:10.1038/tp.2015.78. PubMed PMID: 26080319; PubMed Central PMCID: PMC4490288.

Salminen A, Haapasalo A, Kauppinen A, Kaarniranta K, Soininen H, Hiltunen M. Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. Prog Neurobiol. 2015 Aug;131:1-20. doi: 10.1016/j.pneurobio.2015.05.001. Epub 2015 May 19. Review. PubMed PMID: 26001589.

Jansen WJ, Ossenkoppele R, Knol DL, Tijms BM, Scheltens P, Verhey FR, Visser PJ; Amyloid Biomarker Study Group, Aalten P, Aarsland D, Alcolea D, Alexander M, Almdahl IS, Arnold SE, Baldeiras I, Barthel H, van Berckel BN, Bibeau K, Blennow K, Brooks DJ, van Buchem MA, Camus V, Cavedo E, Chen K, Chetelat G, Cohen AD, Drzezga A, Engelborghs S, Fagan AM, Fladby T, Fleisher AS, van der Flier WM, Ford L, Förster S, Fortea J, Foskett N, Frederiksen KS, Freund-Levi Y, Frisoni GB, Froelich L, Gabryelewicz T, Gill KD, Gkatzima O, Gómez-Tortosa E, Gordon MF, Grimmer T, Hampel H, Hausner L, Hellwig S, Herukka SK, Hildebrandt H, Ishihara L, Ivanoiu A, Jagust WJ, Johannsen P, Kandimalla R, Kapaki E, Klimkowicz-Mrowiec A, Klunk WE, Köhler S, Koglin N, Kornhuber J, Kramberger MG, Van Laere K, Landau SM, Lee DY, de Leon M, Lisetti V, Lleó A, Madsen K, Maier W, Marcusson J, Mattsson N, de Mendonça A, Meulenbroek O, Meyer PT, Mintun MA, Mok V, Molinuevo JL, Møllergård HM, Morris JC, Mroczko B, Van der Mussele S, Na DL, Newberg A, Nordberg A, Nordlund A, Novak GP, Paraskevas GP, Parnetti L, Perera G, Peters O, Popp J, Prabhakar S, Rabinovici GD, Ramakers IH, Rami L, Resende de Oliveira C, Rinne JO, Rodrigue KM, Rodríguez-Rodríguez E, Roe CM, Rot U, Rowe CC, Rüther E, Sabri O, Sanchez-Juan P, Santana I, Sarazin M, Schröder J, Schütte C, Seo SW, Soetewey F, Soininen H, Spiru L, Struyfs H, Teunissen CE, Tsolaki M, Vandenberghe R, Verbeek MM, Villemagne VL, Vos SJ, van Waalwijk van Doorn LJ, Waldemar G, Wallin A, Wallin ÅK, Wiltfang J, Wolk DA, Zboch M, Zetterberg H. Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis. JAMA. 2015 May 19;313(19):1924-38. doi: 10.1001/jama.2015.4668. PubMed PMID: 25988462; PubMed Central PMCID: PMC4486209.

Solomon A, Soininen H. Dementia: Risk prediction models in dementia prevention. Nat Rev Neurol. 2015 Jul;11(7):375-7. doi: 10.1038/nrneurol.2015.81. Epub 2015 May 19. PubMed PMID: 25986502.

Marttinen M, Kurkinen KM, Soininen H, Haapasalo A, Hiltunen M. Synaptic dysfunction and septin protein family members in neurodegenerative diseases. Mol Neurodegener. 2015 Apr 3;10:16. doi: 10.1186/s13024-015-0013-z. Review. PubMed PMID: 25888325; PubMed Central PMCID: PMC4391194.