DilAo - Project:
Prediction of thoracic aortic dilatation in different
Dilatation of thoracic aorta considers “silent killer” because it rarely causes any symptoms until it ruptures. Imaging has an important role in the follow-up of aortic dilation. Currently anatomical magnetic resonance imaging (MRI) and computed tomography (CT) are used to measure aortic diameter which is further used to follow-up aortic dilation. Aortic diameter only fails to predict upcoming speed or severity of aortic dilation.
4D flow MRI can be applied to measure blood flow characteristics and derived parameters in the thoracic aorta, which are hypothesized to predict aortic dilation. We use Siemens 1.5 T MAGNETOM Aera for 4D flow measurements and analyze and visualize data with CAAS MR 4D Flow 2.0 software. The main parameters which are under interest are peak flow velocity, peak flow, regurgitant fraction, flow displacement and wall shear stress.
There are some heritable genetic risk factors and mutations which can cause diseases, e.g. Marfan’s and Loeys-Dietz syndrome, which increase the risk of developing aortic dilatation. Marfan’s syndrome is a disorder of connective tissue, and it’s caused by different mutations on FBN1–gene.
The aim of this study is to find out predictive risk factors for aortic dilatation.
|Streamlines of flow velocity in 4D Flow |
|Wall Shear Stress in thoracic aorta.|
Department of Clinical Radiology
Petteri Kauhanen / BM
Elina Kariniemi / MD
Teemu Kiljander / MD
Seppo Ylä-Herttuala / MD, PhD, Professor
Juha Töyräs / PhD, Professor
Pirjo Mustonen / MD, PhD, Professor
Matti Kurki, Dr. Tech., Head of Department
Kauhanen SP, Hedman M, Kariniemi E, Jaakkola P, Vanninen R, Saari P, et al. Aortic dilatation associates with flow displacement and increased circumferential wall shear stress in patients without aortic stenosis: A prospective clinical study. J Magn Reson Imaging 2019 Jan 18.