Rabbit sedation, anaesthesia and analgesia

SEDATION
To ease small operations, as a premedication to inhalation and propofol anaethesia

1) Hypnorm® (fentanyl citrate 0,315 mg/ml, fluanison 10 mg/ml):   
   0,2 - 0,5 ml/kg sc

2) Domitor® (medetomidine 1mg/ml):  
   0,1-  0,5 mg/kg
   0,1 - 0,5 ml/kg sc

3) Dormicum® (midatsolam 5mg/ml)
   1 - 2 mg/kg
   0,2 - 0,4 ml/kg  iv, ip

Anticholinergic premiedication
Anticholinergic premedication decreases mucus secretion in airways and prevents bradycardia.   Anticholinergic premedication is recommended especially if the rabbit will be intubated. 

Robinul® (glycopyrrolate 0,2 mg/ml)
   0,1 mg/kg sc,im or
   0,01 mg/kg iv

   0,5 ml/kg sc or
   0,05 ml/kg iv

ANAESTHESIA
1) Hypnorm® (fentanyl citratei 0,315 mg/ml, fluanison 10mg/ml)+ Dormicum® (midatsolame 5mg/ml)

Administration:
    Hypnorm® 0,3ml/kg im, sc
    after 10-15 min  Dormicum® 0,2-0,4ml/kg iv, ip

2) Domitor® (medetomidine 1mg/ml)+Ketalar®/Ketaminol® (ketamine 50mg/ml)

Medetomidine 0,25-0,5mg/kg
Ketamine 15-25mg/kg

Administration:
    Domitor® 0,25-0,5ml/kg sc
    Ketalar®/Ketaminol® 0,3-0,5ml/kg sc

Note, that medetomidine  can hinder blood sampling from periferal veins. Medetomidine also increases urine secretion, which has to be taken into account when estimating fluid demand.

3) Rapinovet® (propofol 10mg/ml)

It is  wise to use propofol on rabbits only in short operations. There has been hypotension, hypothermia, lipema and death in the connection of long propofol anaesthesia in rabbits. It might be difficult to find the right dose, in small doses the anaesthesia level is not deep enough and when increasing the dose, the risk of respiratory depression increases rapidly.  

Induction without premedication:
            5 - 15 mg/kg
            0,5 - 1 ml/kg iv

For premedicated animal:
  Induction:
            2 - 3 mg/kg
            0,2 - 0,3ml/kg iv

  Maintenance:
            4,2 mg/kg/h
            0,42 ml/kg/h i.g. 0,1ml/kg q15min iv

Stable and accurate dosing will be received during maintenace phase with infusion pump.

4) Inhalatioanaesthesia, example:
Premedication:
            Hypnorm® (fentanyl citrate 0,315mg/ml, fluanison 10mg/ml)
            0,2 - 0,5 ml/kg sc

            Robinul® (glycopyrrolate 0,2mg/ml)
            0,5 ml/kg sc

Canylation of ear vein:  22G

Induction:
            Dormicum® (midatsolame 5mg/ml)
            0,2 - 0,4ml/kg  iv

Intubation: 3.0 tube

Anaesthesia:
            Isoflurane  2-2,5% + oxygen

Antagonist administratio

Antagonist Anaesthesia Dosing Additional info
Atipamezole (Antisedan® vet 5mg/ml)    α2-agonists: medetomidine, ksylatsine
 
 0,1-1mg/kg im,ip,sc,iv  Very spesific antagonist. Dose depends on the dose of anaesthetic. 
Bubrenorfin (Temgesic® 0,3mg/ml)  opioids that have agonistic effect on μ-reseptors: fentanyl, morfin, methadone 

0,01-0,05mg/kg  

sc, iv, ip, im 

Decreases the sedative effect of opioids, analgetic effect remains.
 

Doksapram (Dopram® 20mg/ml) 

 All  5-10mg/kg im,iv,sc   Stimulates breathing  
Flumazenil (Lanexat® 0,1mg/ml)  Bentsodiatsepins: diatsepam, midatsolam
 
0,5mg/kg iv,im
 
Dose depends on the dose of bentsodiatsepine. 
 
Nalokson(Narcanti® 0,02mg/ml)  Opioids that have agonistic effect on μ-reseptors: fentanyl, morfin, methadone  0,01-0,1mg/kg iv,im,ip  Has antagonistic effect on sedative effect of opioids, removes also analgetic effect. 

analgesia

1) Temgesic® (bubrenorfin 0,3mg/ml)
    0,01 - 0,05 mg/kg

Dosing:
    0,03 - 0,17 ml/kg sc, iv q 6-12h

Attention! Do not give before anaesthesia, that contains fentanyl (e.g. käyttöliuos). Bubrenorfin prevents the sedative effect of fentanyl and you can not get the animal into anaesthesia.  When you use "käyttöliuos", it is best to give bubrenorfin when the animal is waking up.  Bubrenorfin may paralyze intestine function and therefore cause constipation. 

2) Rimadyl injektion solution® (carprofein 50mg/ml)
   4 mg/kg

Dosing:
   0,08 ml/kg sc q 24h max during 3 days


8.6.2010sm