Multiple endocrine neoplasia type 1
Multiple endocrine neoplasia type 1 (MEN-1) is part of a group of disorders that affects the endocrine system. MEN1 occurs when tumors are found in at least two of the three main endocrine glands (parathyroid, pituitary, and pancreatico-duodenum). Tumors can also develop in organs and tissues other than endocrine glands. If the tumors become cancerous, some cases can be life-threatening. The disorder affects 3-20 in 100 000 people. People with MEN 1 are born with one mutated copy of the MEN1 gene in each cell. The MEN1 gene is located on chromosome 11. More than 1 300 mutations in this gene have been described, and the mutations are found in all coding exons (2-10). A mutation or a deletion in the MEN1 gene confirms the diagnosis of MEN1.
The analysis is performed from a whole blood sample (EDTA). Instructions for storage and sending the sample as well as prices for DNA analysis are given in the request form. The report and interpretation of the results are mailed to the address given in the order 6-8 weeks after the arrival of the blood sample.