Serine Hydrolases as Guardians of Bioactive Lipids in Health and Disease

Bioactive lipids, such as eicosanoids, endocannabinoids and lysophospholipids are endogenous signaling molecules with wide spectrum of (patho)physiological functions in regulating cellular activity. Typically, these lipophilic messengers are produced "on demand" from cell membrane precursors and are released by specific enzymatic activity in response to e.g. extracellular stimuli. The levels and signaling function of these lipid mediators are tightly regulated by metabolic enzymes, many of which still remain poorly characterized. Recent findings suggest that deflection from the finely-tuned balance between production and degradation of the bioactive lipids in tissues can ultimately drive physiological metabolic pathways towards pathophysiology, such as cancer.

Group Leaders

Curriculum Vitae

                                                            

Jarmo T. Laitinen, PhD, Docent,

Senior research associate

Juha Savinainen, PhD, Docent,

Senior research associate