Group leader

Anne Maria Koivisto
Chief  Neurologist Consultant
MD, PhD, Special Competence in Medical Education

Department of Neurology
Visiting address:
Building 4, 5th floor
Kuopio University Hospital
Kuopio, Finland
+358-(0)44-717 5629 (mobile)
+358-(0)44- 7173029 (office)
+358-(0)17-172 305 (fax)

anne.koivisto (at)



  • Alzheimer’s disease, Normal Pressure Hydrocephalus and other memory disorders:
    • Early diagnosis, differential diagnostics, disease progression, therapy, genetics, health economics, quality of life research, care
  • Treatment of headaches
  • Improvement of medical education


  • Professor  in Neurology, University of Eastern Finland, 2017

  • Chief Neurologist Consultant (temp), Kuopio University Hospital, 2017

  • Member, Executive Board, NeuroCenter, Kuopio University Hospital, 2017

  • Adjunct Professor in Neurology, University of Eastern Finland 2014 -

  • Member, Executive Board, Institute of Clin. Medicine, University of Eastern Finland, 2012-16

  • Group Leader, PI, ALSOVA- Study, University of Eastern Finland 2010-

  • Chair, Regional Group of Experts to Improve Treatment Chains for Persons with Cognitive Disorder, Kuopio University Hospital/ County of North Savo, Finland 2010 –

  • Senior Researcher, NPH and Early AD studies, University  of Eastern Finland and Kuopio University Hospital, Finland 2008 -

  • Clinical Lecturer, University of Eastern Finland 2007-

  • Senior Neurologist Consultant, Kuopio University Hospital 2005-

  • Senior Researcher, Alzheimer Clinical studies and genetics, University  of Eastern Finland 2006-

  • Investigator, Clinical trials, Kuopio University Hospital and University of Kuopio, 1997-2005


  • Committee Contact person/Chair, Special Competence in Memory Disorders - Committee, Finnish Medical Association

  • Board member, Association for Medical Education in Finland

  • Committee Member, Training and Education, Finnish Neurological Society

  • Committee member, Protection of Interests (University sector), Finnish Medical Association

  • Committee member, Neurology Trust Committee, Finnish Brain Society (Suomen Aivosäätiö)


  • 11 PhD students
    • 4 accepted thesis
    • 7 ongoing theses
  • 3 post-doctoral students


Professor Koivisto has collaborated and is still collaborating with several national and international research groups (since 1997 while working as investigator in multicenter clinical trials (e.g. Exelon, Aricept, Galantamine, Memantine studies) and as researcher in scientific studies.


Hongisto K, Hallikainen I, Selander T, Törmälehto S, Väätäinen S, Martikainen J, Välimäki T, Hartikainen S, Suhonen J, Koivisto AM. Quality of Life in relation to neuropsychiatric symptoms in Alzheimer's disease: 5-year prospective ALSOVA cohort study. Int J Geriatr Psychiatry. 2017 Jan 9. doi: 10.1002/gps.4666. [Epub ahead of print] PubMed PMID: 28067961.

Kojoukhova M, Vanha KI, Timonen M, Koivisto AM, Nerg O, Rummukainen J, Rauramaa T, Vanninen R, Jääskeläinen JE, Sutela A, Leinonen V. Associations of intracranial pressure with brain biopsy, radiological findings, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus. Acta Neurochir (Wien). 2017 Jan;159(1):51-61. doi: 10.1007/s00701-016-3025-8. PubMed PMID: 27878614.

Kokkonen N, Herukka SK, Huilaja L, Kokki M, Koivisto AM, Hartikainen P, Remes AM, Tasanen K. Increased Levels of the Bullous Pemphigoid BP180 Autoantibody Are Associated with More Severe Dementia in Alzheimer's Disease. J Invest Dermatol. 2017 Jan;137(1):71-76. doi: 10.1016/j.jid.2016.09.010. PubMed PMID: 27650606.

Koivisto AM, Hallikainen I, Välimäki T, Hongisto K, Hiltunen A, Karppi P, Sivenius J, Soininen H, Martikainen J. Early psychosocial intervention does not delay institutionalization in persons with mild Alzheimer disease and has impact on neither disease progression nor caregivers' well-being: ALSOVA 3-year follow-up. Int J Geriatr Psychiatry. 2016 Mar;31(3):273-83. doi: 10.1002/gps.4321. PubMed PMID: 26177825.

Välimäki TH, Martikainen JA, Hongisto K, Väätäinen S, Sintonen H, Koivisto AM. Impact of Alzheimer's disease on the family caregiver's long-term quality of life: results from an ALSOVA follow-up study. Qual Life Res. 2016 Mar;25(3):687-97. doi: 10.1007/s11136-015-1100-x. PubMed PMID: 26350541.

Luikku AJ, Hall A, Nerg O, Koivisto AM, Hiltunen M, Helisalmi S, Herukka SK, Sutela A, Kojoukhova M, Mattila J, Lötjönen J, Rummukainen J, Alafuzoff I, Jääskeläinen JE, Remes AM, Soininen H, Leinonen V. Multimodal analysis to predict shunt surgery outcome of 284 patients with suspected idiopathic normal pressure hydrocephalus. Acta Neurochir (Wien). 2016 Dec;158(12):2311-2319. PubMed PMID: 27743250.

Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V. Health-related quality-of-life outcome in patients with idiopathic normal-pressure hydrocephalus - a 1-year follow-up study. Eur J Neurol. 2017 Jan;24(1):58-66. doi: 10.1111/ene.13130. PubMed PMID: 27647684.

Huovinen J, Kastinen S, Komulainen S, Oinas M, Avellan C, Frantzen J, Rinne J, Ronkainen A, Kauppinen M, Lönnrot K, Perola M, Pyykkö OT, Koivisto AM, Remes AM, Soininen H, Hiltunen M, Helisalmi S, Kurki M, Jääskeläinen JE, Leinonen V. Familial idiopathic normal pressure hydrocephalus. J Neurol Sci. 2016 Sep 15;368:11-8. doi: 10.1016/j.jns.2016.06.052. PubMed PMID: 27538594.

Haapalinna F, Paajanen T, Penttinen J, Kokki H, Kokki M, Koivisto AM, Hartikainen P, Solje E, Hänninen T, Remes AM, Herukka SK. Low Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women. Dement Geriatr Cogn Dis Extra. 2016 Jul 19;6(2):303-12. doi: 10.1159/000446425. PubMed PMID: 27504119; PubMed Central PMCID: PMC4965537.

Kurkinen KM, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, Sarajärvi T, Gabbouj S, Kurki M, Paananen J, Koivisto AM, Rauramaa T, Leinonen V, Tanila H, Soininen H, Lucas FR, Haapasalo A, Hiltunen M. SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1. J Cell Sci. 2016 Jun 1;129(11):2224-38. doi: 10.1242/jcs.185215. PubMed PMID: 27084579.

Koivisto AM, Kurki MI, Alafuzoff I, Sutela A, Rummukainen J, Savolainen S, Vanninen R, Jääskeläinen JE, Soininen H, Leinonen V. High Risk of Dementia in Ventricular Enlargement with Normal Pressure Hydrocephalus Related Symptoms1. J Alzheimers Dis. 2016 Mar 22;52(2):497-507. doi: 10.3233/JAD-150909. PubMed PMID: 27031474.

Hongisto K, Väätäinen S, Martikainen J, Hallikainen I, Välimäki T, Hartikainen S, Suhonen J, Koivisto AM. Self-Rated and Caregiver-Rated Quality of Life in Alzheimer Disease with a Focus on Evolving Patient Ability to Respond to Questionnaires: 5-Year Prospective ALSOVA Cohort Study. Am J Geriatr Psychiatry. 2015 Dec;23(12):1280-9. doi: 10.1016/j.jagp.2015.07.002. PubMed PMID: 26560513.

Törmälehto SM, Martikainen JA, Väätäinen ST, Hallikainen IT, Hallikainen M, Bell JS, Koivisto AM. Use of Anti-Dementia Drugs in Relation to Change in Cognition, Behavior, and Functioning in Alzheimer's Disease over a Three-Year Period: Kuopio ALSOVA Study. J Alzheimers Dis. 2015;48(4):1033-41. doi: 10.3233/JAD-150092. PubMed PMID: 26444756.

Välimäki TH, Martikainen JA, Hallikainen IT, Väätäinen ST, Koivisto AM. Depressed Spousal Caregivers Have Psychological Stress Unrelated to the Progression of Alzheimer Disease: A 3-Year Follow-Up Report, Kuopio ALSOVA Study. J Geriatr Psychiatry Neurol. 2015 Dec;28(4):272-80. doi: 10.1177/0891988715598229. PubMed PMID: 26251107.

Kojoukhova M, Koivisto AM, Korhonen R, Remes AM, Vanninen R, Soininen H, Jääskeläinen JE, Sutela A, Leinonen V. Feasibility of radiological markers in idiopathic normal pressure hydrocephalus. Acta Neurochir (Wien). 2015 Oct;157(10):1709-18; discussion 1719. doi: 10.1007/s00701-015-2503-8. PubMed PMID: 26190755.

Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. Health-related quality of life in patients with idiopathic normal pressure hydrocephalus. Eur J Neurol. 2015 Oct;22(10):1391-9. doi: 10.1111/ene.12755. PubMed PMID: 26104064.

Haanpää RM, Suhonen NM, Hartikainen P, Koivisto AM, Moilanen V, Herukka SK, Hänninen T, Remes AM. The CERAD Neuropsychological Battery in Patients with Frontotemporal Lobar Degeneration. Dement Geriatr Cogn Dis Extra. 2015 Apr 14;5(1):147-54. doi: 10.1159/000380815. PubMed PMID: 25999981; PubMed Central PMCID: PMC4439794.

Herukka SK, Rummukainen J, Ihalainen J, von Und Zu Fraunberg M, Koivisto AM, Nerg O, Puli LK, Seppälä TT, Zetterberg H, Pyykkö OT, Helisalmi S, Tanila H, Alafuzoff I, Hiltunen M, Rinne J, Soininen H, Jääskeläinen JE, Leinonen V. Amyloid-β and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus. J Alzheimers Dis. 2015;46(1):261-9. doi: 10.3233/JAD-142862. PubMed PMID: 25720406.

Gilmartin JF, Väätäinen S, Törmälehto S, Bell JS, Lönnroos E, Salo L, Hallikainen I, Martikainen J, Koivisto AM; ALSOVA Study Group.. Depressive symptoms are associated with analgesic use in people with Alzheimer's disease: Kuopio ALSOVA study. PLoS One. 2015 Feb 17;10(2):e0117926. doi: 10.1371/journal.pone.0117926. PubMed PMID: 25688858; PubMed Central PMCID: PMC4331553.

Hallikainen I, Martikainen J, Lin PJ, Cohen JT, Lahoz R, Välimäki T, Hongisto K, Väätäinen S, Vanhanen M, Neumann PJ, Hänninen T, Koivisto AM. The Progression of Alzheimer's Disease Can Be Assessed with a Short Version of the CERAD Neuropsychological Battery: The Kuopio ALSOVA Study. Dement Geriatr Cogn Dis Extra. 2014 Dec 11;4(3):494-508. doi: 10.1159/000369159. PubMed PMID: 25685140; PubMed Central PMCID: PMC4296232.

Helisalmi S, Hall A, Meriläinen EH, Väisänen V, Koivisto AM, Herukka SK, Laitinen M, Soininen H, Hiltunen M. The effect of TOMM40 poly-T repeat lengths on age of onset and cerebrospinal fluid biomarkers in Finnish Alzheimer's disease patients. Neurodegener Dis. 2014;14(4):204-8. doi: 10.1159/000367994. PubMed PMID: 25500937.

Martiskainen H, Helisalmi S, Viswanathan J, Kurki M, Hall A, Herukka SK, Sarajärvi T, Natunen T, Kurkinen KM, Huovinen J, Mäkinen P, Laitinen M, Koivisto AM, Mattila KM, Lehtimäki T, Remes AM, Leinonen V, Haapasalo A, Soininen H, Hiltunen M. Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach. J Alzheimers Dis. 2015;43(2):565-73. doi: 10.3233/JAD-140777. PubMed PMID: 25096612.

Välimäki T, Martikainen J, Hongisto K, Fraunberg M, Hallikainen I, Sivenius J, Vehviläinen-Julkunen K, Pietilä AM, Koivisto AM. Decreasing sense of coherence and its determinants in spousal caregivers of persons with mild Alzheimer's disease in three year follow-up: ALSOVA study. Int Psychogeriatr. 2014 Jul;26(7):1211-20. doi: 10.1017/S1041610214000428. PubMed PMID: 24655686.

Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT, Herukka SK, Koivisto AM, Alafuzoff I, Puli L, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M, Zetterberg H, Leinonen V. Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus. PLoS One. 2014 Mar 17;9(3):e91974. doi: 10.1371/journal.pone.0091974. PubMed PMID: 24638077; PubMed Central PMCID: PMC3956805.

Rinne JO, Frantzen J, Leinonen V, Lonnrot K, Laakso A, Virtanen KA, Solin O, Kotkansalo A, Koivisto A, Sajanti J, Karppinen A, Lehto H, Rummukainen J, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajarvi M, Grachev ID. Prospective flutemetamol positron emission tomography and histopathology in normal pressure hydrocephalus. Neurodegener Dis. 2014;13(4):237-45. doi: 10.1159/000355256. PubMed PMID: 24296542.

Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN, Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau MT, Choi SH, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL, De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman MW, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuiness B, Larson EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M, Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC, Hardy J, Deniz Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M, Matthews F; European Alzheimer's Disease Initiative (EADI).; Genetic and Environmental Risk in Alzheimer's Disease.; Alzheimer's Disease Genetic Consortium.; Cohorts for Heart and Aging Research in Genomic Epidemiology., Moebus S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F, Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannefelt L, Hakonarson H, Pichler S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O, Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H, Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C, de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K, Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL, Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltuenen M, Martin ER, Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A, Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M, Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina V, Seshadri S, Williams J, Schellenberg GD, Amouyel P. with 268 other collaborators …Fernandez C, Aladro Benito Y, Thonberg H, Forshell C, Lilus L, Kinhult-Ståhlbom A, Giedraitis V, Kilander L, Brundin RM, Concari L, Helisalmi S, Koivisto AM, Haapasalo A…. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013 Dec;45(12):1452-8. doi: 10.1038/ng.2802. PubMed PMID: 24162737; PubMed Central PMCID: PMC3896259.

Hallikainen I, Hänninen T, Fraunberg M, Hongisto K, Välimäki T, Hiltunen A, Karppi P, Sivenius J, Soininen H, Koivisto AM; ALSOVA study group.. Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study. Int Psychogeriatr. 2013 Aug;25(8):1335-44. doi: 10.1017/S1041610213000653. PubMed PMID: 23676340.

Elias-Sonnenschein LS, Helisalmi S, Natunen T, Hall A, Paajanen T, Herukka SK, Laitinen M, Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FR, Visser PJ, Soininen H, Hiltunen M. Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort. PLoS One. 2013;8(4):e59676. doi: 10.1371/journal.pone.0059676. PubMed PMID: 23573206; PubMed Central PMCID: PMC3616106.

Leinonen V, Rinne JO, Virtanen KA, Eskola O, Rummukainen J, Huttunen J, von Und Zu Fraunberg M, Nerg O, Koivisto AM, Rinne J, Jääskeläinen JE, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajärvi M, Heurling K, Grachev ID. Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients. Eur J Neurol. 2013 Jul;20(7):1043-52. doi: 10.1111/ene.12102. PubMed PMID: 23398333.

Välimäki T, Vehviläinen-Julkunen K, Pietilä AM, Koivisto A. Life orientation in Finnish family caregivers' of persons with Alzheimer's disease: a diary study. Nurs Health Sci. 2012 Dec;14(4):480-7. doi: 10.1111/j.1442-2018.2012.00721.x. PubMed PMID: 23186523.

Koivisto AM, Alafuzoff I, Savolainen S, Sutela A, Rummukainen J, Kurki M, Jääskeläinen JE, Soininen H, Rinne J, Leinonen V; Kuopio NPH Registry (www.uef.finph).. Poor cognitive outcome in shunt-responsive idiopathic normal pressure hydrocephalus. Neurosurgery. 2013 Jan;72(1):1-8;discussion 8. doi: 10.1227/NEU.0b013e31827414b3. PubMed PMID: 23037817.