Metabolic MR Imaging
Pathological processes, such as inflammation and injury, affect the metabolic balance of brain and other organs. Often the metabolic changes precede structural alterations in tissue and therefore give an early warning sign of the developing disease. Among the common pre-clinical and clinical imaging modalities, MR-based methods are unique in that they allow a non-invasive spatial and chemical separation of a range of tissue metabolites. Furthermore, dissolution dynamic nuclear polarisation (dDNP) method increases sensitivity of 13C-labelled metabolite markers >10,000-fold making real-time in vivo metabolic MR imaging possible.
Our group is interested in the development of novel metabolic MR imaging methods and combining them with advanced 1H MRI to gain a better understanding of potential biomarkers for metabolic diseases in brain and in other organs such as heart.