Microstructural Imaging Group

The brain microenvironment changes during pathology due to processes, such as neurodegeneration, inflammation, plasticity, axonal injury, demyelination, etc. These microstructural changes alter the imaging contrast in magnetic resonance imaging (MRI), which might be potential imaging markers of pathological processes. However, there is a lack of understanding of how tissue alterations in the brain during pathology affect the MRI contrast. This knowledge is the ultimate importance for diagnosing patients during neurodegenerative diseases or brain injury, as well as prediction of clinical outcomes, and guidance of development of novel treatments.

Our group is interested in the application and combination of multiscale imaging modalities to identify and characterize imaging markers after brain injury. Our overall aim is to assess underlying microstructural alterations in brain tissue using non-invasive and advance MRI techniques, and modern histopathological methods.