Molecular Brain Research
The Laboratory of Molecular Brain Research investigates molecular mechanisms of neurodegeneration focusing on models of acute neurodegeneration (stroke, spinal cord injury) and chronic neurodegeneration (Alzheimer's disease, Parkinson's disease and Amyotrophic lateral sclerosis).
We use a number of in vivo and in vitro models of these diseases including genetically modified mouse strains.
In addition, we have generated human induced pluripotent stem cells (iPSCs) from patients with neurodegenerative, psychiatric or cardiac diseases as well as prepared primary cultures of certain human and mouse cells to be used as research tools.
The idea is to investigate the role of key factors, including enzymes, cytokines, receptors and their functions that are involved in immune response and inflammation, oxidative stress or cell death at the molecular and cellular level and verify their significance in the pathogenesis.
We also obtain human body fluids, blood cells and autopsy material to further understand the clinical relevance of these factors.