Molecular Neurodegeneration //
Current activities

  • See our recent publications:
    • PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease. Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J. Stem Cell Reports. 2017 Nov 12. pii: S2213-6711(17)30471-X. doi: 10.1016/j.stemcr.2017.10.016. [Epub ahead of print]
    • DHCR24 exerts neuroprotection upon inflammation-induced neuronal death. Martiskainen H*, Paldanius KMA*, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A*, Hiltunen M*. J Neuroinflammation. 2017 Nov 7;14(1):215. doi: 10.1186/s12974-017-0991-6. *Equal contribution.
    • New Implications for the Role for Ubiquilin-1 in Molecular Mechanisms of Alzheimer's Disease: Interrelationship with BACE1. Takalo M, Natunen T, Leskelä S, Paldanius KMA, Soininen H, Hiltunen M, Haapasalo A. Review Article: J Alzheimers Dis Parkinsonism 2017, 7:365. DOI: 10.4172/2161-0460.1000365
  • We have open Master Thesis projects available.  Please see more details on AIVI open thesis projects page.
  • We are part of the Finnish FTD Research Network, FinFTD
  • We are part of SynaNet, a H2020 consortium on “Neurologic and Psychiatric Disorders: from synapses to networks”
  • We are part of GenomMed Doctoral Programme (

Previous activities

  • Annakaisa Haapasalo, in collaboration with Research Fellow, Head of the UEF Biomarker Laboratory Sanna-Kaisa Herukka (Institute of Clinical Medicine – Neurology) and Professor Asla Pitkänen (AIVI), received UEF strategic funding for a Proof of Concept (PoC) project “From preclinical markers of neuronal damage to biomarkers for brain diseases”. Read more:
  • Malm and Haapasalo research groups hosted a workshop on Neuroinflammation as part of SynaNet activities. Please read more at:
  • We have shown that SEPT8, a member of a family of GTP-binding proteins regulating e.g. vesicular trafficking, modulates β-amyloidogenic processing of APP by affecting BACE1 sorting and levels. Read more: Kurkinen KM et al., J Cell Sci. 2016 Jun 1;129(11):2224-38. doi: 10.1242/jcs.185215. Epub 2016 Apr 15.
  • Our recent publication shows a novel relationship between Alzheimer’s disease-associated ubiquilin-1 and BACE1 in human Alzheimer's disease brain, in the brain of AD transgenic mice and  cell-based models. Read more: Natunen T, Takalo M et al., Neurobiol Dis. 2016 Jan;85:187-205. doi: 10.1016/j.nbd.2015.11.005. Epub 2015 Nov 10.