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Intracranial Aneurysm Group


Neurosurgery of Kuopio University Hospital (KUH) serves Eastern Finnish population

KUH Neurosurgery sIA Group


Juha E Jääskeläinen / Professor Research Director
juha.e.jaaskelainen (at) kuh.fi
+358 44 717 4660

Mikael von und zu Fraunberg / Post Doc
mikael.fraunberg (at) kuh.fi
+358 44 717 2320

Katariina Helin / RN
Kuopio sIA Database
katariina.helin (at) kuh.fi
+358 44 717 2350

Mitja Kurki / Bioinformatician
mitja.kurki (at) uef.fi
+358 40 864 1353

Journal Club

PhD Students

Jukka Huttunen 
Jonas Halonen 
Terhi Huttunen 
Petros Karamanakos 
Antti Lindgren 
Annamaija Riihinen 
Sari Räisänen 
Taavi Saavalainen 
Hanna Tattari 
Anu Ticklen

Timo Koivisto / Associate Professor
timo.koivisto (at) kuh.fi

Jaakko Rinne / Associate Professor
jaakko.rinne (at) kuh.fi

Antti Ronkainen / Associate Professor
antti.ronkainen (at) kuh.fi

Collaborators

Stepani Bendel / Post Doc
KUH Neurointensive Care

Murat Gunel / Professor
Neurosurgery and Genetics / Yale University

Juha Hernesniemi / Professor Chairman
Helsinki Neurosurgery

Seppo Helisalmi / Associate Professor
UEF Neuroscience

Mikko Hiltunen / Associate Professor
UEF Neuroscience

Kai Kaarniranta / Professor
KUH Ophthalmology

Mika Niemelä / Associate Professor
Helsinki Neurosurgery

Aarno Palotie / Professor
Wellcome Sanger Institute Cambridge UK

Seppo Ylä-Herttuala / Professor
UEF Biotechnology and Molecular Medicine

Links 

  • NPH and Early AD Group
  • Finnish Intracranial Aneurysm Research Consortium (FIARC)
  • Kuopio Neuroscience Center
  • Clinical Research Centre / UEF

 

Intracranial Aneurysm Group

Saccular intracranial aneurysm (sIA) and subarachnoid hemorrhage (aSAH)

Some 2% of population develops saccular intracranial aneurysms (sIAs) at the branching sites of major intracranial extracerebral arteries. Subarachnoid hemorrhage (aSAH) due to rupture of the sIA wall is a devastating form of stroke that affects working-age population.

The sIA disease is complex - it is not known how the acquired and inherited risk factors affect the formation of the sIA pouch and/or the rupture of the sIA wall. Such knowledge would facilitate the development of novel biological methods to identify carriers of the sIA disease and to prevent rupture of the sIA wall.

Our group studies the phenotype, longterm outcome, concomitant diseases, overall disease course, and genetics of sporadic and familial Finnish sIA disease as well as the biology of the sIA wall as a member of the Finnish Intracranial Aneurysm Research Consortium (www.fiarc.fi).

We function at the Kuopio Intracranial Aneurysm Database (www.uef.fi/ns), Clinical Research Institute, University of Eastern Finland (UEF), and Neurosurgery of NeuroCenter, Kuopio University Hospital (KUH), Kuopio, Finland.

As of 2011, the database consists of 2.426 sporadic and 477 familial sIA patients (DNA 1.429) from the Eastern Finnish catchment population of KUH area from 1980 to 2007.

We are highly interested in joining forces with European and other collaborators in the sIA disease genetics and biology. Please contact juha.e.jaaskelainen (at) kuh.fi or +358 44 717 4660.
 

We heartily invite new researchers to our team.
Please email your CV and intentions to juha.e.jaaskelainen (at) kuh.fi.

Prognostic model for aSAH from ruptured sIA based on Kuopio Intracranial Aneurysm Database
(not for clinical use): 
  • aSAHmortality 1a (under construction):
    Calculator for individual risk of death after aSAH at any time until 12 months after aSAH. Based on the cohort of 1657 consecutive patients admitted alive within 24 hours after aSAH to KUH between 1980 and 2007 from the Eastern Finnish catchment population. 

Selected publications on the Finnish sIA disease

  • Kurki M, et al. Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll like receptor signaling and NF-kappaB, HIF1A and ETS transcription factors. Neurosurgery 2011
  • Huttunen T, el al. Long-term excess mortality of 244 familial and 1,502 sporadic one-year survivors of aneurysmal subarachnoid hemorrhage as compared to matched Eastern Finnish catchment population. Neurosurgery 2011
  • Huttunen T, et al. Saccular intracranial aneurysm disease: distribution of site, size, and age suggests different etiologies for aneurysm formation and rupture in 316 familial and 1454  sporadic eastern Finnish patients. Neurosurgery 2010
  • Yasuno K, et al. Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet 2010
  • Bilguvar K, et al. Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet 2008
  • Helgadottir A, et al. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008
  • Frosen J, et al. Growth factor receptor expression and remodelling of saccular cerebral artery aneurysm walls: implications for biological therapy preventing rupture. Neurosurgery 2006
  • Tulamo R, et al. Complement activation associates with saccular cerebral artery aneurysm wall degeneration and rupture. Neurosurgery 2006
  • Frosen J, et al. Remodelling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured cases. Stroke 2004
  • van der Voet M, et al. Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3. Am J Hum Genet 2004
  • Ronkainen A, et al. Risk of harboring an unruptured intracranial aneurysm. Stroke 1998
  • Ronkainen A, et al. Familial intracranial aneurysms. Lancet 1997 

 

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